ABO血型与鼻咽癌发生发展及预后的相关性分析

目的探讨ABO血型在鼻咽癌发生发展和预后中的意义。方法将2013年6—12月于湖南省肿瘤医院初次就诊的188例鼻咽癌患者纳入研究,收集患者治疗前血样进行ABO血型以及EBV-DNA检测。对患者随访5年以上,采用Kaplan-Meier法进行生存分析,Log-rank检验比较总生存率的差异。结果不同血型的患者性别、年龄、吸烟史、饮酒史、TNM分期、T分期、N分期、M分期、EBV-DNA水平、放化疗情况均无统计学意义(P>0.05);ABO血型在鼻咽癌患者与正常人群之间的分布差异无统计学意义(P=0.352);ABO血型与鼻咽癌分期、远处转移及EBV-DNA水平无相关性(P>0.05),不同血型患者的总生存率差异也无统计学意义(P=0.215);此外,A型与非A型、B型与非B型、O型与非O型患者的总生存率差异均无统计学意义(P>0.05)。非AB型患者总生存率明显高于AB型患者(P=0.038)。EBV-DNA<4.0×10^(2)copies/ml或EB-DNA≥4.0×10^(2)copies/ml时,不同血型患者的总生存率均无明显差异(P>0.05)。结论 ABO血型与鼻咽癌的发生发展及预后无相关性,ABO血型与EB病毒感染未见明显相关性。

Correlation of ABO blood group with the occurrence,development and prognosis of nasopharyngeal carcinoma

Objective To explore the significance of ABO blood group in the incidence, development and prognosis of nasopharyngeal carcinoma (NPC). Methods One hundred and eighty-eight patients who were newly diagnosed as NPC in Hunan Cancer Hospital from June to December 2013 were enrolled in this study. Blood samples of the patients before treatment were collected for ABO blood group and EBV-DNA testing. All the patients were followed up for more than five years. Kaplan-Meier method was used to draw the survival curve, and Log-rank test was employed to compare the differences in the overall survival (OS) rates. Results There were no statistically significant differences in gender, age, smoking history, drinking history, TNM stage, T stage, N stage, M stage, EBV-DNA level and chemoradiotherapy status of patients with different blood groups (all P>0.05). No statistically significant difference was found in the distribution of ABO blood type between NPC group and the control group (P=0.352). ABO blood group was not correlated with TNM stage, distant metastasis and EBV-DNA level (P>0.05). No statistically significant difference was observed in the OS rates among patients with different blood groups (P=0.215). In addition, there was no statistically significant difference in the OS rates between type A and non-type A groups, between type B and non-type B groups as well as between type O and non-type O groups (all P>0.05). The OS rate was significantly higher in non-AB group than in AB group (P=0.038). When the level of serum EBV-DNA was < 4.0×10²(copies/ml) or ≥ 4.0×10² (copies/ml), no significant difference was discovered in the OS rates among patients with different blood groups (P>0.05). Conclusion ABO blood group has no correlation with the occurrence, development and prognosis of NPC, and also has no significant association with Epstein-Barr virus infection.