老年糖尿病患者低血糖与认知功能障碍的相关性

目的 探讨老年糖尿病低血糖患者的认知功能障碍情况,并分析低血糖与认知功能障碍的相关性.方法 选取2019年6月-2020年6月于空军军医大学第一附属医院就诊的610例老年糖尿病患者为研究对象,依据患者是否发生过低血糖分为重度低血糖组24例,轻度低血糖组277例,非低血糖组309例;依据患者低血糖的发生次数将患者分为低频...

Correlation between hypoglycaemia and cognitive dysfunction in elderly diabetic patients

  Objective  To explore the cognitive dysfunction in elderly diabetic patients with hypoglycaemia and to analyse the correlation between hypoglycaemia and cognitive dysfunction.  Methods  A total of 610 elderly diabetic patients admitted at our hospital from June 2019 to June 2020 were selected as the research subjects. The patients were divided into the severe hypoglycaemia group (n=24), mild hypoglycaemia group (n=277) and non-hypoglycaemia group (n=309). According to the frequency of hypoglycaemia, the patients were divided into the low-frequency group (≤3 times, 351 cases), medium-frequency group (3-7 times, 172 cases) and high-frequency group (≥8 times, 87 cases). Multiple stepwise regression was used to analyse the correlation between hypoglycaemia and cognitive function.  Results  (1) The cognitive function score of the non-hypoglycaemia group [(26.13±1.28) points] was significantly better than that of the mild [(24.92±1.12) points] and severe hypoglycaemia groups [(24.73±1.25) points, F=78.601, P < 0.01]. (2) Statistically significant differences were observed in the incidence of cognitive dysfunction amongst groups with different frequency of hypoglycaemia (P < 0.05). The incidence of cognitive dysfunction was the highest in the high-frequency group (68.97%) and the lowest in the low-frequency group (38.75%). Significant differences were observed in the incidence of cognitive dysfunction amongst groups with different degrees of hypoglycaemia (P < 0.05). The incidence of cognitive dysfunction was the highest in the severe hypoglycaemia group (75.00%) and lowest in the non-hypoglycaemia group (31.07%). (3) The occurrence, frequency and degree of hypoglycaemia were important factors affecting patients' cognitive dysfunction.  Conclusion  Hypoglycaemia is a risk factor for cognitive impairment in diabetic patients. The frequency and degree of hypoglycaemia can affect the cognitive level of elderly diabetic patients.