艰难梭菌与抗生素相关腹泻的研究进展

 抗生素相关性腹泻（AAD）是指应用抗生素后发生的、与抗生素有关的腹泻，是常见的药物不良反应，其发病机制并未完全阐明。艰难梭菌（CD）是一种具有芽孢结构厌氧的肠道致病菌，被认为是引起AAD的常见原因，越来越多研究表明AAD与艰难梭菌感染（CDI）相关，但CD致AAD的作用机制尚不十分明确。本文通过阐明AAD与CD的关系，并从多个方面分析CD致AAD可能作用机制以及目前存在的一些相关治疗方法，以期改进AAD的治疗与预防。

Advances in Clostridium difficile and antibiotic-associated diarrhea

Antibiotic-associated diarrhea (AAD) refers to the diarrhea related to antibiotics after the application of antibiotics, it is a common adverse drug reaction, and its pathogenesis has not been fully elucidated. Clostridium difficile (CD) is an anaerobic enteropathogen with spore structure, which is considered to be a common cause of AAD, more and more studies have shown that AAD is related to CD infection (CDI), but the mechanism of CD-induced AAD is not very clear. This paper elucidates the relationship between AAD and CD, analyzes the possible mechanism of CD-induced AAD and some currently existing treatment methods from multiple aspects, so as to improve the treatment and prevention of AAD.