非小细胞肺癌免疫治疗研究进展

近年来,肺癌的治疗手段层出不穷,从传统化疗到靶向药物,再到免疫检查点抑制剂的出现,很大程度上改善了患者的预后,延长了患者生存期.免疫检查点抑制剂的应用,即免疫治疗,一改传统的治疗方式,作用于程序性细胞死亡蛋白-1(PD-1)及其配体(PD-L1)发挥有效且持久的抗肿瘤反应.本文主要介绍了近年来免疫治疗一线、二线应用于非...

Progress in immunotherapy of non-small cell lung cancer

In recent years,the treatment of lung cancer has emerged in endlessly,from traditional chemotherapy to targeted drugs,and then to the emergence of immunocheckpoint inhibitors,which has greatly improved the prognosis of patients and prolonged their survival.The use of immunological checkpoint inhibitors,ie immunotherapy,has changed the traditional treatment modality to exert an effective and long-lasting anti-tumor response to programmed cell death protein-1 (PD-1) and its ligand (PD-L1).This paper mainly introduces the research status of the first-line and second-line application of immunotherapy in non-small cell lung cancer (NSCLC) in recent years,the factors affecting the efficacy of immunotherapy,and the related adverse reactions of immunotherapy.