鲍曼不动杆菌的调控性非编码RNA与抗菌药物耐药

 鲍曼不动杆菌是医院感染常见病原菌之一。多重耐药菌，甚至全耐药菌的出现给世界公共卫生安全带来极大的威胁。近年来，多项试验研究证明，细菌可在抗菌药物等压力条件下通过产生特异性的ncRNAs或通过其构像的变化调控相关耐药基因的表达，在调节细菌的耐药性等方面起着重要作用。总结调控性非编码RNAs对鲍曼不动杆菌耐药性的调控作用及其作为药物靶点的研究，以期为应对鲍曼不动杆菌耐药问题提供帮助。

Regulatory non-coding RNAs and antimicrobial resistance of Acinetobacter baumannii

Acinetobacter baumannii is one of the common pathogens causing healthcare-associated infection, the emergence of multidrug-resistant organisms, even pandrug-resistant organisms, poses a great threat to the world public health security. In recent years, a number of experimental studies have proved that bacteria can regulate the expression of relevant antimicrobial resistance genes by generating specific non-coding RNAs (ncRNAs) or changing their conformation under the pressure of antimicrobial agents, and play an important role in regulating antimicrobial resistance of bacteria. This review summarizes the research on regulatory role of regulatory ncRNAs on antimicro-bial resistance of Acinetobacter baumannii and ncRNAs as drug targets, in order to provide help to deal with the problem of antimicrobial resistance of Acinetobacter baumannii.