细菌药物主动外排系统在生物被膜耐药中的作用 |
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引用本文: | 王清会,凌保东.细菌药物主动外排系统在生物被膜耐药中的作用[J].中国抗生素杂志,2021,46(10):917-921. |
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作者姓名: | 王清会 凌保东 |
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摘 要: | 摘要:细菌生物被膜的产生使传统抗菌药物难以对其进行有效的清除,进而导致严重感染的复发和持续性感染, 是人类目
前面临的又一新的挑战。生物被膜细菌中由于营养物质和代谢产物的积累,促使药物主动外排系统相关基因表达明显增加, 使
外排泵转运多种不同类型的化合物能力增强,从而产生多重耐药表型,是引起细菌耐药的主要机制之一;外排泵基因的表达对
生物被膜细菌的生长和耐药性增强方面有着重要作用。本文从生物被膜耐药的影响因素、药物主动外排系统参与生物被膜形成
及其影响、外排泵抑制剂对生物被膜耐药的影响几个方面对细菌药物主动外排系统在生物被膜耐药中的作用进行综述。
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Effect of bacterial efflux pump system on biofilm resistance |
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Abstract: | Abstract The formation of bacterial biofilms makes it difficult for traditional antibacterial drugs to effectively
remove them, which in turn leads to the recurrence of serious infections and persistent infections. It is yet another new
global challenge facing humanity. The accumulation of nutrients and metabolic waste in the biofilm bacteria promotes
a significant increase in the expression of related genes in the active efflux system of the drug, and enables the efflux
pump to transport a variety of different types of compounds, resulting in multiple drug resistance phenotypes, which
is caused by bacterial resistance one of the main mechanisms; the expression of efflux pump genes plays an important
role in the growth of biofilm bacteria and the enhancement of drug resistance. In this paper, the factors affecting the
biofilm resistance, the active drug efflux system participating in the biofilm formation and its impact, and the effect of
the efflux pump inhibitor on the biofilm resistance are several aspects of resistance to the bacterial drug active efflux
system in the biofilm. The role in the review is reviewed. |
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