预后营养指数对恶性胸膜间皮瘤患者疗效和预后的预测价值

目的:探讨治疗前的预后营养指数(prognostic nutritional index,PNI)在恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)患者中化疗疗效以及预后判定中的作用.方法:回顾性分析2006年01月01日至2019年12月31日中国医科大学肿瘤医院的52例MPM患...

Clinical significance of prognostic nutritional index in predicting the efficacy and outcomes of malignant pleural mesothelioma

Objective:To evaluate the clinical significance of prognostic nutritional index (PNI) in predicting efficacy and outcomes in patients with malignant pleural mesothelioma (MPM).Methods:The clinical data from 52 patients with MPM,who were diagnosed in the Liaoning Provincial Cancer Hospital from January 1,2006 to December 31,2019,were retrospectively analyzed.Their clinical and laboratory data were collected.The PNI was calculated as serum albumin value (g/L) + 5×total lymphocyte count (×109/L) in peripheral blood.We used univariate and multivariate analyses to identify the efficacy and prognostic factors.Results:Mean pretreatment PNI was 46.8.Pretreatment PNI was significantly associated with gender(P=0.012),tumor type based on the chest CT (P=0.015),TNM stage (P=0.010) and the efficacy of chemotherapy on first-line (P=0.000).The patients with higher pretreatment PNI (PNI>46.8) had better efficacy to chemotherapy than those patients with lower PNI (PNI≤46.8).Survival analysis showed pretreatment PNI was an independent prognostic factor in MPM.Compared with patients with higher PNI (PNI>46.8),patients with lower PNI (PNI≤46.8) had greater risk of death (hazard ratio:2.323;95% confidence interval:1.125~4.799,P=0.023).Conclusion:The level of pretreatment PNI could provide certain basis for efficacy evaluation.The lower PNI is related to poor prognosis in MPM.Pretreatment PNI is an independent prognostic factor in MPM.