低幅高频振动对比格犬种植体周围骨愈合和种植体骨结合的影响

目的:低幅高频(low-magnitude high-frequency,LMHF)振动已被证实在骨愈合中起到重要作用.本研究旨在评估LMHF振动直接加载于纯钛种植体后,对种植体周骨愈合及种植体骨结合的影响.方法 :6 只拔除下颌前磨牙及磨牙的雄性比格犬常规饲养3 个月后,在双侧下颌骨前磨牙及磨牙区分别植入3 颗纯钛种...

The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs

PURPOSE: Low-magnitude, high-frequency（LMHF） loading has been confirmed to play an important role in bone healing. The present study aimed to evaluate the effect of LMHF loading applied directly to titanium dental implants on peri-implant bone healing and implant. METHODS: The mandibular premolars and molars were extracted from six male Beagle dogs. Three months post-extraction, six titanium implants (Aadva Standard Implant Narrow, 3.3 mm×8 mm) were inserted into the mandibular premolar and molar area (three implants per side) in each of the six dogs. In each animal, one side was randomly selected to undergo daily LMHF loading (experimental group), while the other side had no further intervention (control group). The loading was applied directly to the implant abutment using an individual jig and a custom-made loading device (8 μm,100 Hz). The implant stability quotient (ISQ) was tested every week. Three dogs were euthanized after 2 weeks, and three were euthanized after 8 weeks. Tissue samples were fixed and stained for micro-computed tomography(micro-CT) and histomorphometric analyses. The data were statistically analyzed using SPSS 13.0 software package. RESULTS: The experimental group had significantly increased peri-implant bone volume relative to tissue volume in region of interest 2 (100-500 μm) compared with the control group after 2 weeks of loading (P<0.05); however, there was no significant difference between the two groups after 8 weeks (P>0.05). The ISQ value and the micro-CT results did not differ between the two groups during the study period. CONCLUSIONS: LMHF loading positively influences peri-implant bone healing and osseointegration in the early healing period.