| 尿液游离DNA检测及其在肿瘤诊治中应用的研究进展 |
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| 引用本文： | 徐冬冬1,黄 花2. 尿液游离DNA检测及其在肿瘤诊治中应用的研究进展[J]. 现代肿瘤医学, 2021, 0(13): 2347-2350. DOI: 10.3969/j.issn.1672-4992.2021.13.033 |
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| 作者姓名： | 徐冬冬1 黄 花2 |
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| 作者单位： | 1.川北医学院法医学系，四川 南充 637000;2.南充市第二人民医院老年疾病科，四川 南充 637000 |
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| 基金项目： | 四川省基层卫生事业发展研究中心（编号:SWFZ16-Z-46） |
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| 摘 要： | 尿液中的游离DNA来源于尿道脱落细胞的崩解和通过尿道过滤屏障的血液循环cfDNA。作为液体活检的重要对象，尿中游离DNA可能成为一种新型的标记物用于肿瘤无创筛查与诊断、病情监测和疗效评估。本文将对尿液游离DNA的提取与检测方法及其在多种肿瘤的临床应用等方面的研究进展进行总结综述。
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| 关 键 词： | 尿液 游离DNA 肿瘤 标记物 |
Research progress of urine free DNA detection and its application diagnosis and treatment in tumor |
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| XU Dongdong1,HUANG Hua2. Research progress of urine free DNA detection and its application diagnosis and treatment in tumor[J]. Journal of Modern Oncology, 2021, 0(13): 2347-2350. DOI: 10.3969/j.issn.1672-4992.2021.13.033 |
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| Authors: | XU Dongdong1 HUANG Hua2 |
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| Affiliation: | 1.Department of Forensic Medicine，North Sichuan Medical College,Sichuan Nanchong 637000,China;2.Department of Geratology,the Second People Hospital of Nanchong，Sichuan Nanchong 637000,China. |
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| Abstract: | Free DNA in urine is derived from the breakdown of cells shed from the urethra and circulating cfDNA through the urethra filtration barrier.As an integral part of liquid biopsy,cell free DNA in urine is considered to be a new non-invasive marker for tumor screening and diagnosis,tumor progression monitoring and efficacy evaluation.This article will summarize the research progress in the extraction and detection of urine free DNA and its clinical application in a variety of tumors. |
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| Keywords: | urine cfDNA tumor biomarkers |
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