| 细粒棘球蚴和多房棘球蚴感染对Balb/c小鼠淋巴细胞亚群的影响 |
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| 引用本文： | 曹得萍,张耀刚,姜博璠,李建华,庞明泉,陈根. 细粒棘球蚴和多房棘球蚴感染对Balb/c小鼠淋巴细胞亚群的影响[J]. 中国人兽共患病杂志, 2021, 37(5): 421-425. DOI: 10.3969/j.issn.1002-2694.2021.00.057 |
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| 作者姓名： | 曹得萍 张耀刚 姜博璠 李建华 庞明泉 陈根 |
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| 作者单位： | 1. 桂林医学院基础学院,桂林 541199;2. 青海大学附属医院包虫病重点实验室,西宁 810001;3. 广州医科大学第三附属医院检验科,广州 510145;4. 青海大学附属医院肝胆胰外科,西宁 810001 |
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| 基金项目： | 国家重点研发计划项目(No.2017YFC0909900)、青海省科技厅基础研究计划项目(No.2018-ZJ-921)联合资助 |
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| 摘 要： | 目的 分析Balb/c小鼠感染细粒棘球蚴和多房棘球蚴后脾脏和血液淋巴细胞亚群的变化.方法 利用流式细胞仪分析感染细粒棘球蚴和多房棘球蚴的Balb/c小鼠脾脏和血液中T、B、Th1、Th2、Treg、NK细胞亚群变化.结果 脾脏B、Th1、Th2、Treg细胞在多房棘球蚴感染组和对照组比较,差异有统计学意义;血液Th1和...
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| 关 键 词： | 细粒棘球蚴 多房棘球蚴 Balb/c小鼠 脾脏 血液 淋巴细胞亚群 |
| 收稿时间： | 2020-10-16 |
The effects of hydatid cyst and alveolar hydatid infection on lymphocyte subsets in Balb/c mice |
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| CAO De-ping,ZHANG Yao-gang,JIANG Bo-fan,LI Jian-hua,PANG Ming-quan,CHEN Gen. The effects of hydatid cyst and alveolar hydatid infection on lymphocyte subsets in Balb/c mice[J]. Chinese Journal of Zoonoses, 2021, 37(5): 421-425. DOI: 10.3969/j.issn.1002-2694.2021.00.057 |
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| Authors: | CAO De-ping ZHANG Yao-gang JIANG Bo-fan LI Jian-hua PANG Ming-quan CHEN Gen |
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| Affiliation: | 1. Basic Medical College of Guilin Medical University, Guilin 541199,China;2. Echinococcosis Key Laboratory of the Affiliated Hospital of Qinghai Univeristy, Xining 810001,China;3. Clinical Lab of the Third Affiliated Hospital of Guangzhou Medical Univerisity, Guangzhou 510145,China;4. Department of Hepatobiliary and Pancreatic Surgery of the Affiliated Hospital of Qinghai Univeristy, Xining 810001,China |
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| Abstract: | This study aimed to analyze lymphocyte subsets in spleen and blood of Balb/c mice infected by hydatid cyst and alveolar hydatid. Flow cytometry was used to analyze T, B, Th1, Th2, Treg and NK lymphocyte in spleen and blood of Balb/c mice with hydatid cyst and alveolar hydatid infection. B, Th1, Th2 and Treg cells in spleen of mice with alveolar hydatid infected group and control group were statistical difference; The difference of Th1 and Th2 cells between the alveolar hydatid infected group and the control group were statistical significance (tTh1=3.669, P<0.01; tTh2=4.302, P<0.01). B, Th1, Th2 and Treg cells in spleen of mice with hydatid cyst infected group and control group were statistical difference (tB=3.396,P<0.05;tTh1=3.539,P<0.05;tTh2=3.731,P<0.05;tTreg=2.197,P<0.05); B, NK, Th1 and Th2 cells between the hydatid cystgroup and the control group were statistical significance (tB=2.125,P<0.05;$t_{N_{K}}$=3.569,P<0.05;tTh1=6.532,P<0.05;tTh2=4.463,P<0.05). B, Th1, Th2 and Treg cells in both hydatid cyst and alveolar hydatid infected group showed the same trend. There were changes of Th1 and Th2 cells in the blood of alveolar hydatid infected group. There were changes of B, NK, Th1 and Th2 in the blood of hydatid cyst infected group. |
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| Keywords: | hydatid cyst alveolar hydatid Balb/c mice spleen blood lymphocyte subsets |
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