| 分子标志物在高级别胶质瘤患者预后评估中的价值 |
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| 引用本文： | 吴 静1,陈绪珠2,马 强3,曲冰杰4,梁俊福1. 分子标志物在高级别胶质瘤患者预后评估中的价值[J]. 现代肿瘤医学, 2021, 0(24): 4309-4311. DOI: 10.3969/j.issn.1672-4992.2021.24.009 |
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| 作者姓名： | 吴 静1 陈绪珠2 马 强3 曲冰杰4 梁俊福1 |
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| 作者单位： | 1.北京怀柔医院影像科；4.病理科，北京 101400；2.首都医科大学附属北京天坛医院放射科，北京 100050；3.首都医科大学附属宣武医院血液科，北京 100053 |
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| 基金项目： | National Natural Science Foundation of China(No.81772005）；国家自然科学基金资助项目(编号:81772005) |
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| 摘 要： | 目的:探讨分子标志物在高级别胶质瘤患者预后评估中的价值。方法:收集2010年09月至2015年07月之间经我院收治的高级别胶质瘤患者31例，免疫组织化学染色检测患者肿瘤组织中Ki-67、6-氧-甲基鸟嘌呤-DNA甲基转移酶（MGMT）、表皮生长因子受体（EGFR）、p53和基质金属蛋白酶-9（MMP-9）的表达；电话及门诊随访患者生存状况，分析上述分子标志物在高级别胶质瘤患者预后评估中的价值。结果:Ki-67和MGMT高表达患者的PFS明显低于低表达患者（P＜0.05），但MMP-9、EGFR和p53表达水平与PFS间未见明显相关性（P＞0.05）。多因素分析发现Ki-67是影响PFS的独立预后因素(RR=5.19，P＜0.05)。结论:Ki-67是影响高级别胶质瘤患者PFS的独立危险因素，在预后评估中可能具有潜在的应用价值。
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| 关 键 词： | 高级别胶质瘤 分子标志物 无进展生存期 |
The prognostic value of molecular markers in patients with high-grade glioma |
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| WU Jing1,CHEN Xuzhu2,MA Qiang3,QU Bingjie4,LIANG Junfu1. The prognostic value of molecular markers in patients with high-grade glioma[J]. Journal of Modern Oncology, 2021, 0(24): 4309-4311. DOI: 10.3969/j.issn.1672-4992.2021.24.009 |
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| Authors: | WU Jing1 CHEN Xuzhu2 MA Qiang3 QU Bingjie4 LIANG Junfu1 |
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| Affiliation: | 1.Department of Radiology;4.Department of Pathology,Beijing Huairou Hospital,Beijing 101400,China;2.Department of Radiology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050，China;3.Department of Hematology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China. |
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| Abstract: | Objective:To evaluate the prognostic value of molecular markers in patients with high-grade glioma.Methods:From September 2010 to July 2015,31 patients with high-grade glioma were collected and confirmed by pathology.Immunohistochemistry was used to detect the expression levels of Ki-67,O6-methylguanine-DNA methyltransferase (MGMT),epidermal growth factor receptor (EGFR),p53 and matrix metalloproteinase-9 (MMP-9) in tumor tissues.Survival status was obtained by telephone and outpatient follow-up.The prognostic value of molecular markers was evaluated in patients with high-grade glioma patients.Results:Ki-67 and MGMT expression had significant effect on PFS (P＜0.05),while MMP-9,EGFR and p53 had no effect on PFS (P＞0.05).Multivariate Cox proportional hazard model analysis showed that Ki-67 was an independent prognostic factor affecting PFS (RR=5.19，P＜0.05).Conclusion:Ki-67 is an independent prognostic factor of PFS in patients with high-grade glioma,which may have potential application value in prognostic evaluation. |
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| Keywords: | high-grade glioma molecular marker progression-free survival |
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