| 软骨寡聚基质蛋白与疾病关系的研究进展 |
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| 引用本文： | 金炼驰,赖永洁△.软骨寡聚基质蛋白与疾病关系的研究进展[J].天津医药,2021,49(3):330-336. |
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| 作者姓名： | 金炼驰 赖永洁△ |
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| 作者单位： | 1遵义医科大学珠海校区/贵州省免疫学研究生创新研究基地（邮编519041）；2遵义医科大学珠海校区免疫学与病原生物学教研室 |
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| 基金项目： | 国家自然科学基金青年基金项目（81700341），贵州省自然科学基金（黔科合基础［2020］1Y297），贵州省教育厅科学基金（黔教合KY字［2017］184） |
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| 摘 要： | 软骨寡聚基质蛋白（COMP）为细胞外基质（ECM）中的非胶原糖蛋白，通过其不同结构域与组织中的多种ECM、细胞表面黏附分子、生长因子等相互作用，参与了多种疾病的发病过程，并发挥不同作用。本文就COMP的基本结构、功能，以及在骨关节系统病变、心血管系统疾病、组织纤维化和癌症等疾病发生过程中发挥的作用进行了综述。
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| 关 键 词： | 软骨寡聚基质蛋白质 细胞外基质 生物标记 纤维化 |
| 收稿时间： | 2020-09-11 |
| 修稿时间： | 2020-11-29 |
Research progress on the role of cartilage oligomeric matrix protein in human diseases |
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| JINLian-chi,LAIYong-jie△.Research progress on the role of cartilage oligomeric matrix protein in human diseases[J].Tianjin Medical Journal,2021,49(3):330-336. |
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| Authors: | JINLian-chi LAIYong-jie△ |
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| Institution: | 1 Zhuhai Campus of Zunyi Medical University/Education and Innovation Base for Immunology Graduate Students in Guizhou Province, Zhuhai 519041, China; 2 Department of Immunology and Pathogenic Biology,
Zhuhai Campus of Zunyi Medical University |
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| Abstract: | Cartilage oligomeric matrix protein (COMP) is a non-collagenous glycoprotein component of extracellular matrix (ECMs). COMP interacts with other ECMs, cell adhesive proteins, growth factors via its multi-functional domains. COMP is known to play a role in the development of miscellaneous human diseases. This paper reviews the basic structure and function of COMP and its role in the pathogenesis of joint and cardiovascular diseases, tissue fibrosis and cancer. |
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| Keywords: | cartilage oligomeric matrix protein extracellular matrix biomarkers fibrosis |
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