| 雄激素受体（AR)在HER-2过表达型乳腺癌中的作用及机制研究进展 |
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| 引用本文： | 吴 洋,宋燕妮.雄激素受体（AR)在HER-2过表达型乳腺癌中的作用及机制研究进展[J].现代肿瘤医学,2021,0(16):2913-2917. |
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| 作者姓名： | 吴 洋 宋燕妮 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院乳腺外科，黑龙江 哈尔滨 150081 |
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| 基金项目： | National Natural Science Foundation of China(No.81302286/H1622）；国家自然科学基金项目（编号:81302286/H1622）；中国博士后科学基金项目（编号:2016M590209）；教育部“春晖计划”合作科研项目（编号:HLJ2019010）；黑龙江省自然科学基金项目（编号:LH2020H120）；哈医大附属肿瘤医院海燕科研基金项目（编号:JJZD2020-04） |
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| 摘 要： | 人表皮生长因子受体-2（human epidermal growth factor receptor-2，HER-2）过表达型乳腺癌是乳腺癌中具有侵袭性的亚型之一，与其他类型乳腺癌相比，此类型疾病进展迅速，易复发转移，且预后差。近年来，研究表明雄激素受体（androgen receptor,AR）在HER-2过表达型乳腺癌中高表达。因此，本文将对AR在HER-2过表达型乳腺癌中的作用机制，对预后的影响及最新研究进展进行综述，以期为未来研究提供新的思路。
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| 关 键 词： | 雄激素受体 HER-2过表达型乳腺癌 表达及预后 |
Research progress of the role and mechanism of AR in HER-2 overexpressing breast cancer |
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| WU Yang,SONG Yanni.Research progress of the role and mechanism of AR in HER-2 overexpressing breast cancer[J].Journal of Modern Oncology,2021,0(16):2913-2917. |
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| Authors: | WU Yang SONG Yanni |
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| Institution: | Department of Breast Surgery,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China. |
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| Abstract: | Human epidermal growth factor receptor-2(HER-2) overexpressing breast cancer is one of the aggressive subtypes of breast cancer,compared with other types of breast cancer,this type of disease progresses rapidly,is prone to recurrence and metastasis,and has a poor prognosis.In recent years,studies have confirmed that androgen receptor(AR) is highly expressed in HER-2 overexpressing breast cancer.Therefore,this article will review the mechanism of AR in HER-2 overexpressing breast cancer,its impact on prognosis,and the latest research progress,in order to provide new ideas for future research. |
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| Keywords: | androgen receptor HER-2 overexpressing breast cancer expression and prognosis |
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