PI3K抑制剂在乳腺癌治疗中的应用现状

PI3K/Akt/mTOR信号通路是细胞内的重要信号通路,在调节肿瘤细胞的增殖、分化、转移过程中发挥重要作用.该信号通路的激活与多种肿瘤的发生和发展有密切关系.随着近些年对分子生物学的深入研究发现,磷脂酰肌醇3-激酶(PI3K)通路的异常激活在乳腺癌中最为常见,也使得该通路成为乳腺癌新的治疗靶点,现已研发出多种作用于P...

Current status of PI3K inhibitors in the treatment of breast cancer

Abstract: PI3K/Akt/mTOR signaling pathway is an important signaling pathway in cells, which plays an important role in regulating the proliferation, differentiation and metastasis of tumor cells. The activation of this signaling pathway is closely related to the occurrence and development of many tumors. With the in-depth study of molecular biology in recent years, it has been found that abnormal activation of the phosphatidylinositol 3-kinase (PI3K) pathway is the most common in breast cancer, making this pathway a new therapeutic target for breast cancer. A variety of targeted drugs that act on each protein of the PAM pathway have been developed. In this review, we will discuss the principles of targeting PI3K/AKT/mTOR signals and the current status of the application of PI3K inhibitors in breast cancer treatment. It is expected to provide a theoretical basis for individualized treatment of breast cancer.