| miRNA-152在肝癌组织中的表达及临床意义 |
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| 引用本文： | 彭契六,韦尚谋,张磊,甘丽英,谢珍,陈巧佩,韦邦宁,张智. miRNA-152在肝癌组织中的表达及临床意义[J]. 肿瘤防治研究, 2021, 48(8): 769-773. DOI: 10.3971/j.issn.1000-8578.2021.21.0296 |
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| 作者姓名： | 彭契六 韦尚谋 张磊 甘丽英 谢珍 陈巧佩 韦邦宁 张智 |
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| 作者单位： | 1. 530201 南宁，广西国际壮医医院检验科；2. 530021 南宁，广西壮族自治区妇幼保健院临床检验部；3. 530201 南宁，广西国际壮医医院肝胆外科；4. 530022 南宁，南宁市第一人民医院肝胆外科 |
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| 基金项目： | 广西自然科学基金面上项目（2017JJA10583）；南宁市科学研究与技术开发计划项目（20163126）；2019年广西中医药大学引进博士科研启动基金项目（2019BS042） |
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| 摘 要： | 目的 探讨微小RNA(miR)-152在肝癌组织中的表达及临床意义.方法 收集56例肝癌患者癌及癌旁组织标本,采用实时荧光定量聚合酶链反应技术(Real-time PCR)检测肝癌及癌旁组织标本中miR-152的表达水平,分析其与肝癌患者临床病理特征及预后的相关性.结果 miR-152在肝癌及癌旁组织中相对表达水平分别...
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| 关 键 词： | 肝癌 微小RNA-152 总生存期 预后 |
| 收稿时间： | 2021-03-17 |
Expression and Clinical Significance of miRNA-152 in Hepatocellular Carcinoma |
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| PENG Qiliu,WEI Shangmou,ZHANG Lei,GAN Liying,XIE Zhen,CHEN Qiaopei,WEI Bangning,ZHANG Zhi. Expression and Clinical Significance of miRNA-152 in Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2021, 48(8): 769-773. DOI: 10.3971/j.issn.1000-8578.2021.21.0296 |
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| Authors: | PENG Qiliu WEI Shangmou ZHANG Lei GAN Liying XIE Zhen CHEN Qiaopei WEI Bangning ZHANG Zhi |
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| Affiliation: | 1. Department of Clinical Laboratory, Guangxi International Zhuang Medicine Hospital, Nanning 530201, China; 2. Department of Clinical Laboratory, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning 530021, China; 3. Department of Hepatobiliary Surgery, Guangxi International Zhuang Medicine Hospital, Nanning 530201, China; 4. Department of Hepatobiliary Surgery, The First People’s Hospital of Nanning, Nanning 530022, China |
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| Abstract: | Objective To investigate the expression of microRNA-152 in hepatocellular carcinoma, and analyze the correlation of miR-152 expression with the clinicopathological characteristics of hepatocellular carcinoma(HCC) patients. Methods Real-time PCR was used to detect the expression of miR-152 in tissue specimens from HCC and the adjacent non-cancerous hepatic tissues collected from 56 patients who underwent surgical treatment for primary HCC. The association between the expression of miR-152 and the clinical pathological characteristics and prognosis of HCC patients was analyzed. Results The relative expression of miR-152 in hepatocellular carcinoma and corresponding adjacent non-carcinoma tissues were 0.616±0.041 and 0.768±0.042 (P=0.011). The expression of miR-152 was significantly associated with TNM stages (P=0.042), tumor differentiation (P=0.035), metastasis (P=0.048) and venous invasion (P=0.042). There was no significant association between the miR-152 expression and gender, age, AFP level, tumor number or tumor grade. The OS (P=0.035) and PFS (P=0.012) in the low miR-152 expression group were obviously shorter than those in the high miR-152 expression group. Multivariate Cox regression analysis showed that the low expression of miR-152, tumor recurrence and pathological classification were significant independent prognostic factors for the prognosis of hepatocellular carcinoma patients. Conclusion The expression of miR-152 is decreased in hepatocellular carcinoma tissues, and the low expression of miR-152 is significantly associated with TNM stages, tumor differentiation, metastasis, venous invasion and the prognosis of HCC patients. |
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| Keywords: | Hepatocellular carcinoma MicroRNA-152 Overall survival Prognosis |
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