| CD8+T淋巴细胞浸润与三阴性乳腺癌新辅助化疗疗效的关系 |
| |
| 引用本文： | 孔天东,陈露,段方方,王留晏,周寒丽,赵晓丽,刘萌萌,刘丹娜. CD8+T淋巴细胞浸润与三阴性乳腺癌新辅助化疗疗效的关系[J]. 肿瘤防治研究, 2021, 48(5): 484-488. DOI: 10.3971/j.issn.1000-8578.2021.20.1191 |
| |
| 作者姓名： | 孔天东 陈露 段方方 王留晏 周寒丽 赵晓丽 刘萌萌 刘丹娜 |
| |
| 作者单位： | 1. 450000 郑州,河南大学肿瘤医院（郑州市第三人民医院）乳腺肿瘤科;2. 450000 郑州,河南大学肿瘤医院（郑州市第三人民医院）病理科;3. 450000 郑州,河南大学肿瘤医院（郑州市第三人民医院）GCP中心 |
| |
| 基金项目： | 河南省科技厅攻关计划（172102310455）;郑州市科技攻关计划（20130532） |
| |
| 摘 要： | 目的 探讨三阴性乳腺癌组织CD8+T淋巴细胞浸润（CD8+Tils）的特点与患者预后的关系。方法 回顾性分析术前行新辅助化疗的126例三阴性乳腺癌患者的临床病理资料,采用免疫组织化学法分析CD8+Tils与临床病理特征的关系;Kaplan-Meier法绘制生存曲线,Cox风险比例回归模型分析患者无病生存时间（DFS）的预后影响因素。结果 高密度CD8+Tils浸润与年龄<60岁、病理高分级、临床高分期显著相关（P<0.05）。CD8+Tils高密度浸润患者术后pCR率较低密度组高（66.7% vs. 19.8%, P=0.000）。高密度组中位DFS显著长于CD8+Tils低密度组（49 vs. 25月, P<0.05）。多因素分析显示病理高分级、肿瘤直径>2 cm 、淋巴结转移、脉管侵犯、CD8+Tils低密度浸润均为预后不良影响因素（P<0.05）,CD8+Tils为独立预后因素。结论 CD8+Tils有可能是三阴性乳腺癌患者独立预后指标,高密度浸润患者术后pCR率高、DFS长、远期疗效更优。
|
| 关 键 词： | 三阴性乳腺癌 CD8+T淋巴细胞浸润 新辅助化疗 |
| 收稿时间： | 2020-10-14 |
Relation Between CD8+T Lymphocyte Infiltration and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer |
| |
| KONG Tiandong,CHEN Lu,DUAN Fangfang,WANG Liuyan,ZHOU Hanli,ZHAO Xiaoli,LIU Mengmeng,LIU Danna. Relation Between CD8+T Lymphocyte Infiltration and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2021, 48(5): 484-488. DOI: 10.3971/j.issn.1000-8578.2021.20.1191 |
| |
| Authors: | KONG Tiandong CHEN Lu DUAN Fangfang WANG Liuyan ZHOU Hanli ZHAO Xiaoli LIU Mengmeng LIU Danna |
| |
| Affiliation: | 1. Breast Oncology Department, Cancer Hospital of Henan University (The Third People's Hospital of Zhengzhou), Zhengzhou 450000, China; 2. Pathology Department, Cancer Hospital of Henan University (The Third People’s Hospital of Zhengzhou), Zhengzhou 450000, China; 3. GCP Center, Cancer Hospital of Henan University (The Third People’s Hospital of Zhengzhou), Zhengzhou 450000, China |
| |
| Abstract: | Objective To investigate the relation between the characteristics of CD8+T lymphocyte infiltration and the prognosis of triple-negative breast cancer patients. Methods We retrospectively analyzed the clinicopathological data of 126 patients with triple-negative breast cancer undergoing preoperative neoadjuvant chemotherapy. Immunohistochemical staining was used to analyze the relation between CD8+T lymphocyte infiltration and clinicopathological characteristics. Kaplan-Meier method was used to draw the survival curve, and Cox risk ratio regression model was used to analyze the prognostic factors affecting disease-free survival time (DFS). Results High-density CD8+Tils was associated with age <60 years old, high pathological grade and high clinical stage (P<0.05). The pCR rate of high-density CD8+Tils group was higher than that of the low-density group (66.7% vs. 19.8%, P=0.000). The median DFS of the high-density group was significantly longer than that of the low-density group (49 vs. 25 months, P<0.05). Multivariate analysis showed that high pathological grade, tumor diameter >2 cm, lymph node metastasis, vascular invasion and CD8+Tils low-density infiltration were factors for poor prognosis (P<0.05), and CD8+Tils was an independent prognostic factor. Conclusion CD8+Tils may be an independent prognostic indicator for triple-negative breast cancer. The patients with high-density infiltration have high postoperative pCR rate, long DFS and better long-term efficacy. |
| |
| Keywords: | Triple-negative breast cancer CD8+T lymphocyte infiltration Neoadjuvant chemotherapy |
|
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
|
点击此处可从《肿瘤防治研究》下载全文 |
|
