| 骨形态发生蛋白-7参与糖尿病肾病发病机制的研究进展 |
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| 引用本文： | 张颖超,米焱,王彩丽.骨形态发生蛋白-7参与糖尿病肾病发病机制的研究进展[J].天津医药,2021,49(10):1107-1111. |
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| 作者姓名： | 张颖超 米焱 王彩丽 |
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| 作者单位： | 内蒙古科技大学包头医学院第一附属医院肾内科（邮编014010） |
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| 基金项目： | 骨形态发生蛋白7修饰的骨髓间充质干细胞对糖尿病肾病纤维化的修复及相关机制 |
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| 摘 要： | 糖尿病肾病是危害糖尿病患者健康的严重微血管并发症，以微量白蛋白尿、肾小球基底膜增厚、细胞外基
质沉积、肾小球肥大和系膜扩张为主要特征。在糖尿病肾病发生、发展过程中，骨形态发生蛋白（BMP）-7作为转化
生长因子（TGF）-β超家族的一员发挥多种生物学功能，参与肾小球系膜细胞扩张度、足细胞凋亡、肾小管损伤以及
肾脏纤维化的调节。围绕BMP-7与TGF-β/Smads信号通路、PI3K/Akt信号通路以及间充质干细胞在糖尿病肾病中
的作用机制进行论述，以期为相关研究提供参考。
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| 收稿时间： | 2021-03-29 |
| 修稿时间： | 2021-04-28 |
Advances of bone morphogenetic protein -7 in the pathogenesis of diabetic nephropathy |
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| ZHANG Ying-chao,MI Yan,WANG Cai-li.Advances of bone morphogenetic protein -7 in the pathogenesis of diabetic nephropathy[J].Tianjin Medical Journal,2021,49(10):1107-1111. |
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| Authors: | ZHANG Ying-chao MI Yan WANG Cai-li |
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| Institution: | Department of Nephrology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and
Technology, Baotou 014010, China
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| Abstract: | Diabetic nephropathy is a serious microvascular complication that endangers the health of diabetic patients.
It is mainly characterized by microalbuminuria, glomerular basement membrane thickening, extracellular matrix deposition,
glomerular hypertrophy and mesangial membrane dilatation. In the development of this disease, bone morphogenetic protein
-7 (BMP-7), as a member of the transforming growth factor β (TGF-β) superfamily, plays a variety of biological functions. It
is involved in the regulation of renal mesangial cell dilation, podocyte apoptosis, renal tubule injury and renal fibrosis. In this
paper, we discussed the mechanism of BMP-7 and TGF- β/Smads signaling pathway, PI3K/Akt signaling pathway and
mesenchymal stem cells in diabetic nephropathy, in order to provide reference for the related research. |
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