甲状腺乳头状癌组织中S100A14与LOXL2的表达及临床意义

目的 探讨钙结合蛋白S100A14与赖氨酰氧化酶（LOXL）2在甲状腺乳头状癌（PTC）中的表达及临床意义。方法 收集90例甲状腺病变组织蜡块，制成组织芯片，用免疫组织化学法分别检测S100A14与LOXL2蛋白在30例结节性甲状腺肿组织（NG）、30例经典型甲状腺乳头状癌（CPTC）组织及30例高侵袭性甲状腺乳头状癌组织中的表达情况，探讨S100A14和LOXL2表达与甲状腺乳头状癌临床病理特征的关系。结果 S100A14和LOXL2在PTC组织中普遍高表达，在NG组、CPTC组、高侵袭组中的表达呈逐步递增趋势，S100A14在有淋巴结转移PTC组织中的阳性率高于无淋巴结转移PTC组（P<0.05），且在CPTC组和高侵袭组阳性率表达差异有统计学意义（P<0.05）；S100A14与LOXL2表达呈正相关（r=0.332）。结论 S100A14和LOXL2高表达可能与甲状腺乳头状癌恶性生物学行为、侵袭性有关，同时S100A14可能促进了淋巴结转移。

Expression and Clinical Significance of S100A14 and LOXL2 in Papillary Thyroid Carcinoma

Objective To investigate the expression and clinical significance of S100A14 and LOXL2 in papillary thyroid carcinoma tissues. Methods Paraffin blocks from 90 cases of thyroid lesion were collected to make tissue microarray. The expression of S100A14 and LOXL2 in 30 cases of nodular goiter (NG), 30 cases of classic papillary thyroid carcinoma (CPTC) and 30 cases of high invasion papillary thyroid carcinoma were detected by immunohistochemistry. The correlation of S100A14 and LOXL2 expression with the clinicopathological characteristics of papillary thyroid carcinoma patients was investigated. Results S100A4 and LOXL2 were highly expressed in papillary thyroid carcinoma. There was a gradually increasing trend from the expression in NG group, CPTC group to high invasive group. The positive rate of S100A14 in papillary thyroid carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P<0.05). There was significant difference of S100A14 and LOXL2 expression between CPTC group and high invasion group (P<0.05). S100A14 expression was positively correlated with LOXL2 expression (r=0.332). Conclusion The high expression of S100A14 and LOXL2 may be related to the malignant biological behavior and invasiveness of papillary thyroid carcinoma, and S100A14 may promote lymph node metastasis.