慢性肾脏病患者血清Periostin水平与左心室肥厚的相关性研究

目的 探讨慢性肾脏病（CKD）患者血清Periostin水平与左心室肥厚（LVH）的相关性。方法 选取CKD患 者136例，根据估算肾小球滤过率（eGFR）将患者分为A组（Ⅰ~Ⅱ期，56例）、B组（Ⅲ期，38例）、C组（Ⅳ~Ⅴ期，42例）； 另选取同期体检健康者30例作为对照组。比较CKD不同分期患者临床资料及血清Periostin水平差异，Pearson法分 析CKD患者血清Periostin与其他指标的相关性。根据CKD患者是否合并LVH将其分为LVH组（32例）和非LVH组 （104例），比较2组一般资料及血清Periostin水平差异，Logistic回归分析CKD患者并发LVH的危险因素。结果 （1） 对照组、A 组、B 组、C 组的收缩压、舒张压、同型半胱氨酸（HCY）、肌酐（SCr）、尿素氮（BUN）、左心室质量指数 （LVMI）、Periostin均逐渐升高，组间比较差异均有统计学意义（P＜0.05）。（2）CKD患者血清Periostin与收缩压、HCY、 SCr、BUN、LVMI 均呈正相关（P＜0.05）。（3）LVH 组患者收缩压、舒张压、HCY、SCr、BUN、LVMI、Periostin 均高于非 LVH 组，差异有统计学意义（P＜0.05）；Logistic 回归分析结果显示，收缩压（OR=1.793，95%CI：1.018~3.160）、HCY （OR=1.978，95%CI：1.118~3.499）、Periostin（OR=2.119，95%CI：1.332~3.372）升高均是CKD患者并发LVH的独立危险 因素（P＜0.05）。结论 CKD患者血清Periostin水平呈异常高表达，且其表达水平与患者的左心室肥厚情况密切相关。

Study on the correlation between serum Periostin level and left ventricular hypertrophy in patients with chronic kidney disease

Objective To investigate the correlation between serum Periostin level and left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). Methods A total of 136 CKD patients were selected. According to the estimated glomerular filtration rate (eGFR), the patients were divided into 3 groups: A (stage Ⅰ-Ⅱ, n=56), B (stage Ⅲ, n=38) and C (stage Ⅳ-Ⅴ, n=42). In addition, 30 healthy individuals who had physical examinations during the same period were selected as the control group. The difference of serum Periostin levels and general data in patients with different stages of CKD were compared. Pearson method was used to analyze the correlation between serum Periosti and other indexes in patients with CKD. According to whether CKD patients were combined with LVH, they were divided into the LVH group (n= 32) and the non-LVH group (n=104). The general data and serum levels of Periostin were compared between the two groups. The risk factors of CKD patients with LVH were analyzed by Logistic regression. Results (1) Systolic blood pressure, diastolic blood pressure, homocysteine (HCY), creatinine (SCr), urea nitrogen (BUN), left ventricular mass index (LVMI) and Periostin increased gradually in group A, B and C, and there were significant differences between any two of indicators (P＜ 0.05). (2) The serum levels of Periodin in CKD patients were positively correlated with systolic blood pressure, HCY, SCr, BUN and LVMI (P＜0.05). (3) The systolic blood pressure, diastolic blood pressure, HCY, SCr, BUN, LVMI and Periodin were significantly higher in the LVH group than those of the non-LVH group (P＜0.05). (4) Logistic regression analysis showed that the increased systolic blood pressure (OR=1.793, 95%CI: 1.018-3.160), HCY (OR=1.978, 95%CI: 1.118-3.499) and Periotin (OR=2.119, 95%CI: 1.332-3.372) were independent risk factors for CKD patients with LVH (P＜0.05). Conclusion The serum level of Periostin is abnormally high in CKD patients, and its expression level is closely related to left ventricular hypertrophy.