高毒力肺炎克雷伯菌的研究进展

摘要：肺炎克雷伯菌是一种重要的条件致病菌，常引起社区和医院感染。根据毒力的不同，分为高毒力肺炎克雷伯菌和普 通肺炎克雷伯菌。高毒力肺炎克雷伯菌是一种毒力更强的肺炎克雷伯菌进化型，影响其毒力的因素主要包括：荚膜多糖、黏液 表型调控基因、铁载体和可移动的遗传元件等。高毒力肺炎克雷伯菌主要在亚太地区流行，近年来其耐药株分离率明显上升。 本文将对高毒力肺炎克雷伯菌的流行情况、高毒力相关因素、耐药情况及其检测方法作一介绍。

Research progress of hypervirulent Klebsiella pneumoniae

Klebsiella pneumoniae is an important conditional pathogen, usually causing clinical infections. According to the pathogenicity, it can be divided into classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP). hvKp is an evolving pathotype that is more virulent than cKP. Studies have found that the virulence factors of hvKP include: Capsular polysaccharides, the regulator of mucoidphenotype gene, siderophore, and mobile genetic elements. hvKP is mainly prevalent in the Asian Pacific Rim. In recent years, the isolation rate of drug-resistant strains has increased significantly. In this paper, the epidemic status, the high virulence-related factors, the current status of drug resistance, and the detection method of hvKP are reviewed.