极性蛋白Pard3在乳腺癌组织中的表达及与临床病理特征的相关性

目的:探讨极性蛋白Pard3在乳腺癌组织中的表达及与临床病理特征的相关性。方法:收集2017年6月至2019年12月我院外科行乳腺癌切除术的93例女性乳腺癌患者的乳腺癌组织、癌旁正常组织和临床资料。采用免疫组化技术检测Pard3在乳腺癌组织和癌旁正常组织中的表达情况，并结合临床资料，分析Pard3在乳腺癌组织中的表达量与患者临床病理特征之间的关系。采用二分类的Logistic回归分析进行Pard3在乳腺癌组织中的表达与患者临床病理特征相关性分析。结果:免疫组化结果显示，在乳腺癌组织中Pard3的表达水平明显下降。乳腺癌组织中阳性率为31.2%（29/93），显著低于癌旁正常组织中的阳性率72.0%（67/93），差异有统计学意义（P=0.000）。临床病理特征相关性分析结果显示Pard3的表达与患者年龄、肿瘤大小、病理类型、淋巴结转移情况之间的关系差异无统计学意义（P＞0.05）；与TNM分期、组织分化程度、ER、PR、HER-2、Ki-67表达之间的关系差异有统计学意义（P＜0.05）。经Logistic回归分析结果显示，Pard3的表达与分化程度、ER表达呈正相关，与TNM分期呈负相关，与PR、HER-2、Ki-67表达无相关性。结论:极性蛋白Pard3在乳腺癌组织中的表达显著低于癌旁正常组织，其在乳腺癌组织中的表达量与组织分化程度、ER表达呈正相关，与TNM分期呈负相关。

Polar protein Pard3 expression in breast cancer and its correlation with clinicopathological characteristics

Objective:To investigate the expression of polar protein Pard3 in breast cancer and its correlation with clinicopathological characteristics.Methods:The breast cancer tissue,normal tissues and clinical data of 93 female breast cancer patients who underwent breast cancer resection in our hospital from June 2017 to December 2019 were collected.Immunohistochemical technique was used to detect the expression of Pard3 in breast cancer tissues and normal tissues adjacent to the cancer,and combined with clinical data,the relationship between Pard3 expression in breast cancer tissues and clinical pathological characteristics of patients was analyzed.The Logistic regression analysis of binary classification was used to analyze the correlation between Pard3 expression in breast cancer and clinicopathological characteristics of patients.Results:Immunohistochemical results showed that the expression level of Pard3 in breast cancer tissues decreased significantly.The positive rate in breast cancer tissues was 31.2% (29/93),which was significantly lower than that in normal tissues adjacent to cancer,72.0% (67/93),the difference was statistically significant (P=0.000).The correlation analysis results of clinicopathological characteristics showed that the relationship between Pard3 expression and the patient's age,tumor size,pathological type,and lymph node metastasis were not statistically significant (P＞0.05).There were statistically significant differences in relationship with TNM stage,tissue differentiation,ER,PR,HER-2,Ki-67 expression (P＜0.05).Logistic regression analysis showed that Pard3 expression was positively correlated with the degree of differentiation and ER expression,but negatively correlated with TNM stage,and had no correlation with PR,HER-2 and Ki-67 expression.Conclusion:The expression of polar protein Pard3 in breast cancer tissue is significantly lower than that in normal tissues adjacent to the cancer.Its expression in breast cancer tissue is positively correlated with tissue differentiation and ER,and negatively correlated with TNM stage.