糖尿病视网膜病变患者广泛视网膜光凝术后黄斑色素光密度的变化

目的 探讨糖尿病视网膜病变(DR)患者行广泛视网膜光凝术(PRP)后黄斑色素光密度(MPOD)的变化.方法 纳入我院2018年8月至2020年10月收治的DR患者74例(98眼),所有患者均行PRP治疗,记录PRP的激光斑点总面积、激光能量,分别在术前及术后1周、3个月、6个月检测MPOD值,包括黄斑区平均光密度(DM...

Study on the changes of macular pigment optical density in patients with diabetic retinopathy after panretinal photocoagulation

Objective　To explore the changes of macular pigment optical density (MPOD) in patients with diabetic retinopathy (DR) after panretinal photocoagulation (PRP).Methods　A total of 74 patients (98 eyes) with DR admitted to our hospital from August 2018 to October 2020 were enrolled. All patients were treated with PRP, the total laser spot area and laser energy of PRP were recorded, and MPOD before the operation, 1 week, 3 months and 6 months after the operation were obtained, including the mean macular optical density (D_Mean) and the maximum macular optical density (D_Max). At the same time, the patients’ central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT) were measured. The relationship between MPOD of patients after operation and CRT and SFCT was observed. Results　The D_Mean of the patients at 1 week, 3 months, and 6 months after operation are (0.25±0.08) du, (0.20±0.08) du, (0.19±0.06) du, and D_Max are (0.38±0.06) du, (0.34±0.05) du, (0.33±0.07) du, all these values are lower than the preoperative D_Mean of (0.30±0.09) du and D_Max of (0.48±0.07) du. The CRT and SFCT results of the patients at 1 week after operation are (266.53±47.51) μm and (361.92±64.28) μm, which are higher than the preoperative (240.51±43.62) μm and (326.49±76.43) μm. The CRT results of the patients at 3 and 6 months after operation are (241.92±45.89) μm and (239.84±48.82) μm, respectively, and the SFCT results are (328.17±70.56) μm and (325.31±68.72) μm, respectively, which are lower than those at 1 week after operation (P<0.05). D_Mean and D_Max values of patients over 50 years old with preoperative LDL≥4.12 mmol·L^-1 and laser energy ≥283.39 mW are lower than those of patients less than 50 years old with preoperative LDL<4.12 mmol·L^-1 and laser energy< 283.39 mW. The D_Max value of patients with preoperative TG≥2.17 mmol·L^-1 is (0.33±0.06) du, which is lower than that of patients with preoperative TG<2.17 mmol·L^-1, that is (0.38±0.05) du (P<0.05). The postoperative D_Mean and D_Max of the patients are negatively correlated with laser energy (P<0.05).Conclusion　The MPOD value of patients with DR is lower after operation. The change of MPOD value is closely related to the laser energy during PRP. Preoperative dyslipidemia and age may be confounding factors.