| PI3K/Akt信号通路在眼科疾病发生发展过程中的调控作用研究进展 |
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| 引用本文： | 李晓萌,于颖欣,胡贵丽,刘小菁,毕宏生,郭大东. PI3K/Akt信号通路在眼科疾病发生发展过程中的调控作用研究进展[J]. 眼科新进展, 2021, 0(6): 588-592. DOI: 10.13389/j.cnki.rao.2021.0123 |
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| 作者姓名： | 李晓萌 于颖欣 胡贵丽 刘小菁 毕宏生 郭大东 |
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| 作者单位： | 250014 山东省济南市，山东中医药大学（李晓萌，于颖欣，胡贵丽，刘小菁）；250002 山东省济南市，山东省中西医结合眼病防治重点实验室，山东省高校中西医结合眼病防治技术重点实验室，山东中医药大学眼科研究所（毕宏生，郭大东） |
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| 摘 要： | 眼科疾病的发生发展与眼组织的异常发育和功能障碍有关,其中相关信号通路的活化在眼科疾病的发生和发展过程中发挥重要作用.PI3 K/Akt信号通路(磷脂酰肌醇3激酶/蛋白激酶B信号通路)广泛存在于各类细胞中,是参与细胞生长、增殖、分化调节的重要信号转导通路.研究发现,PI3 K/Akt信号通路在白内障、糖尿病视网膜病变等多...
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| 关 键 词： | PI3K/Akt信号通路 眼科疾病 调控作用 |
Research advance in the regulatory role of PI3K/Akt signaling pathway in the occurrence and development of eye diseases |
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| LI Xiaomeng1,YU Yingxin1,HU Guili1,LIU Xiaojing1,BI Hongsheng2,GUO Dadong2. Research advance in the regulatory role of PI3K/Akt signaling pathway in the occurrence and development of eye diseases[J]. Recent Advances in Ophthalmology, 2021, 0(6): 588-592. DOI: 10.13389/j.cnki.rao.2021.0123 |
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| Authors: | LI Xiaomeng1 YU Yingxin1 HU Guili1 LIU Xiaojing1 BI Hongsheng2 GUO Dadong2 |
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| Affiliation: | 1.Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China2.Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong,Eye Institute of Shandong University of Traditional Chinese Medicine,Jinan 250002,Shandong Province,China |
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| Abstract: | The occurrence and development of eye diseases are related to the abnormal development and dysfunction of the eye tissues, and the activation of the relevant signaling pathways plays an important role in the occurrence and development of eye diseases. PI3K/Akt signaling pathway (phosphatidylinositol 3 kinase/protein kinase B signaling pathway) is widely distributed in various kinds of cells, and is an important signal transduction pathway involved in cell growth, proliferation, differentiation and regulation. It has been found that the PI3K/Akt signaling pathway is abnormally activated in cataract, diabetic retinopathy and other eye diseases, regulating the occurrence and development of eye diseases. We will give a briefly review on the regulatory role of the PI3K/Akt signaling pathway in the occurrence and development of various eye diseases in this paper. |
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| Keywords: | PI3K/Akt signaling pathway eye disease regulatory role |
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