肝癌免疫治疗的研究热点及可视化分析

目的 比较国内外肝癌免疫治疗的研究现状和热点。方法 检索PubMed数据库和中文数据库建库以来至2019年发表的有关肝癌免疫治疗的文献，运用BICOMB-2软件对文献资料进行提取和统计，得到高频主题词的词篇矩阵和共现矩阵，使用gCLUTO 1.0进行聚类分析，NetDraw 2.089绘制社会网络图，并利用UCINET 6.212进行中心度分析。结果 纳入的外文文献和查重后的中文文献分别为2 081篇和901篇，涉及外文期刊655种，中文期刊275种。确定了肝癌免疫治疗研究的四大主题：乙肝患者的免疫接种与肝癌发生情况的相关研究；树突状细胞与肝癌免疫治疗的相关研究；放射疗法与免疫治疗相结合对于肝癌治疗的研究；自然杀伤细胞与肝癌免疫治疗的相关研究。结论 肝癌免疫治疗的研究发表量近年来呈逐年上升趋势，我国可借鉴国际上的研究现状和热点开辟出肝癌治疗的新途径。

Visual Analysis and Focused Areas of Immunotherapy for Liver Cancer Based onLiterature Data

Objective To compare the research status and hotspots of immunotherapy for liver cancer at home and abroad. Methods Papers about immunotherapy for liver cancer published from the establishment to 2019 were searched in PubMed database and Chinese database. Information were extracted and sorted by BICOMB-2 software, and then we created the word matrix and co-occurrence matrix of high-frequency subject headings. The cluster analysis of subject headings was conducted by gCLUTO 1.0. NetDraw 2.089 was used to draw social network diagrams, UCINET 6.212 was used to conduct the centrality analysis. Results There were 2 081 foreign literatures and 901 Chinese literatures, involving 655 foreign periodicals and 275 Chinese periodicals. Four themes of immunotherapy for liver cancer were determined: the correlation between the immune inoculation of hepatitis B patients and the occurrence of liver cancer, the study between dendritic cells and immunotherapy for liver cancer, the study of the combination of radiotherapy and immunotherapy on liver cancer, and related research of natural killer cells and liver cancer immunotherapy. Conclusion The number of researches on immunotherapy for liver cancer have shown an increasing trend year by year. We can learn from the international research status and hotspots to create a new way for liver cancer treatment.