伦敦沙门菌的流行与耐药性分析

目的 分离鉴定2016-2018年不同宿主来源的伦敦沙门菌,并对其进行药物敏感性分析。方法通过生化实验和肠毒素基因stn检测进行种属鉴定;参照考夫曼怀特表对沙门菌进行血清型分型;采用琼脂稀释法测定伦敦沙门菌对18种抗菌药物的敏感性。结果成功分离鉴定出135株伦敦沙门菌,分离自猪、人、犬和鸡来源的样品;100%伦敦沙门菌至少对一种抗菌药物表现耐药;伦敦沙门菌对四环素(95.6%)、链霉素(93.3%)和氨苄西林(87.4%)的耐药率较高,对氨曲南(8.9%)和头孢噻肟(11.1%)耐药率较低,对阿米卡星、多粘菌素、呋喃妥因和美罗培南敏感;多重耐药率达到95.6%,常见的多重耐药表型为AMP-CHL-FFC-FOS-GEN-OLA-STR-SXT-TET。结论伦敦沙门菌主要分离自猪全产业链各环节样品和体检人员样品,其耐药性和多重耐药性严重。

Prevalence and antimicrobial resistance of Salmonella London

This study aimed to explore the drug resistance and prevalence of Salmonella London from different host sources from 2016 to 2018. The species were identified by biochemical testing and stn detection; the serotype of Salmonella was determined according to the Kaufman-White table; the sensitivity of Salmonella London to 18 antibiotics was determined with the agar broth dilution method. The results showed that 135 strains of Salmonella London were successfully isolated and identified, mainly from pig and human samples; 100% of Salmonella London strains were resistant to at least one antibiotic. The resistance rates of Salmonella London to tetracycline (95.6%), streptomycin (93.3%) and ampicillin (87.4%) were high; the resistance rates to aztreonam (8.9%) and cefotaxime (11.1%) were low; and the strains were sensitive to amikacin, polymyxin, nitrofurantoin and meropenem. The common multidrug resistance spectrum was AMP-CHL-FFC-FOS-GEN-OLA-STR-SXT-TET. Salmonella London was mainly isolated from all pig industry chain samples and physical examination personnel samples, and its drug resistance and multiple drug resistance were found to be severe. This study provides important information for the monitoring and prevention of drug resistance in Salmonella London.