| 人兽共患带科绦虫丝氨酸蛋白酶抑制剂研究进展 |
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| 引用本文： | 宋伟宜,王昕蕊,于铭川,崔亚轩,齐昱,孙树民.人兽共患带科绦虫丝氨酸蛋白酶抑制剂研究进展[J].中国血吸虫病防治杂志,2021,33(6):650-654. |
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| 作者姓名： | 宋伟宜 王昕蕊 于铭川 崔亚轩 齐昱 孙树民 |
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| 作者单位： | 内蒙古民族大学动物科技学院（内蒙古 通辽 028000） |
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| 基金项目： | 国家重点研发计划（2017YFD0501303）；国家自然科学基金（32160842，31960707，31460658）；内蒙古自治区自然科学基金（2021MS03037，2017MS0321） |
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| 摘 要： | 丝氨酸蛋白酶抑制剂是一类能抑制丝氨酸蛋白酶活性的蛋白超家族,通过抑制宿主蛋白酶活性协助寄生虫感染宿主.本文从丝氨酸蛋白酶抑制剂空间结构与分类、丝氨酸蛋白酶抑制剂与宿主机体免疫应答间的作用机制及当前人兽共患带科绦虫丝氨酸蛋白酶抑制剂相关研究进展等方面进行阐述,为人兽共患带科绦虫及其中绦期幼虫感染引发疾病诊断、药物治疗靶点...
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| 关 键 词： | 人兽共患病 带科绦虫 丝氨酸蛋白酶抑制剂 免疫逃避 |
Progress of researches on serine protease inhibitors for zoonotic cestode family Taeniidae |
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| SONG Wei⁃yi,WANG Xin⁃rui,YU Ming⁃chuan,CUI Ya⁃xuan,QI Yu,SUN Shu⁃min.Progress of researches on serine protease inhibitors for zoonotic cestode family Taeniidae[J].Chinese Journal of Schistosomiasis Control,2021,33(6):650-654. |
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| Authors: | SONG Wei⁃yi WANG Xin⁃rui YU Ming⁃chuan CUI Ya⁃xuan QI Yu SUN Shu⁃min |
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| Institution: | College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China |
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| Abstract: | Serine protease inhibitor, a protein superfamily that inhibits the serine protease activity, protects hosts from parasitic infections. This review describes the spatial structure and classification of serine protease inhibitor, mechanisms underlying the interplay between serine protease inhibitor and host immune responses and current advances in serine protease inhibitor of zoonotic cestode family Taeniidae, so as to provide insights into the diagnosis of zoonotic tapeworm infections, discovery of therapeutic targets and screening of vaccine candidates. |
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| Keywords: | Zoonosis Cestode family Taeniidae Serine protease inhibitor Immune escape |
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