ACBD3蛋白在乳腺癌组织中的表达及其与患者预后的相关性

目的:分析酰基辅酶A结合结构域蛋白3（acyl CoA binding domain containing protein 3,ACBD3）在乳腺癌组织中的表达及其与患者预后的相关性。方法:选择2013年01月至2014年05月我院收治的乳腺癌患者54例，获取相应癌组织样本及癌旁组织样本各54份。采用免疫组化法检测两组组织标本中ACBD3的表达情况，并分析ACBD3表达与乳腺癌患者病理因素的关系。对不同ACBD3表达情况乳腺癌患者随访5年的生存情况进行讨论。结果:ACBD3在乳腺癌组织中的表达量明显高于癌旁组织［（0.325±0.113） vs （0.058±0.012）］（P＜0.05）；ACBD3的高表达与患者年龄、病理类型、肿瘤直径无关（P＞0.05），与组织分化情况、淋巴结转移、TNM分期有关（P＜0.05）；随访5年，ACBD3高表达患者存活率明显低于ACBD3低表达患者（62.07% vs 88.00%）（P＜0.05）；ACBD3高表达患者5年无进展生存（PFS）率明显低于ACBD3低表达患者（37.93% vs 68.00%）。结论:乳腺癌组织中ACBD3的表达水平明显增加，ACBD3高表达与乳腺癌发展及转移关系密切，且其对患者预后具有一定判断价值。

Expression of ACBD3 in breast cancer tissues and its correlation with the prognosis of patients

Objective:To analysis the ACBD3 expression in breast cancer tissues and its correlation with the prognosis of patients.Methods:54 patients with breast cancer were selected from January 2013 to May 2014 in our hospital.54 samples of corresponding cancer tissue and 54 samples of adjacent tissues were obtained.Immunohistochemistry was used to detect the expression of ACBD3 in tissue samples of two groups.The relationship between the expression of ACBD3 and pathological factors was analyzed.The survival of breast cancer patients with different expression of ACBD3 was discussed after 5-year follow-up.Results:The expression of ACBD3 in breast cancer tissues was significantly higher than that in adjacent tissues［(0.325±0.113) vs (0.058±0.012)］(P＜0.05).The high expression of ACBD3 was not correlated with age,pathological type and tumor diameter（P＞0.05),but with pathological differentiation,lymph node metastasis and TNM stage（P＜0.05).After 5 years of follow-up,the survival rate of patients with high expression of ACBD3 was significantly lower than that of patients with low expression of ACBD3（62.07% vs 88.00%)（P＜0.05).Five-year progression-free survival（PFS) rate in patients with high expression of ACBD3 was significantly lower than that in patients with low expression of ACBD3（37.93% vs 68.00%).Conclusion:The expression of ACBD3 in breast cancer tissues increased significantly.The high expression of ACBD3 is closely related to the development and metastasis of breast cancer,and it has certain value in judging the prognosis of patients.