| m6A甲基化在肿瘤中修饰非编码RNA的最新研究进展 |
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| 引用本文： | 易佑财,张 靖,陈晓宇,朱金水.m6A甲基化在肿瘤中修饰非编码RNA的最新研究进展[J].现代肿瘤医学,2021,0(10):1825-1828. |
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| 作者姓名： | 易佑财 张 靖 陈晓宇 朱金水 |
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| 作者单位： | 上海交通大学附属第六人民医院消化科，上海 200233 |
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| 基金项目： | National Natural Science Foundation of China(No.81873143,81573747）;国家自然科学基金面上项目（编号:81873143,81573747） |
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| 摘 要： | 非编码RNA（non-coding RNA,ncRNA）在细胞分化、血管生成、免疫应答、炎症反应以及肿瘤发生发展中具有重要作用。m6A（N6-methyladenosine）甲基化是真核生物中最常见的RNA修饰方式之一，主要见于信使RNA（messenger RNA，mRNA）。m6A甲基化修饰主要有三种酶参与完成，包括甲基转移酶、去甲基化酶和甲基化识别酶，并且在昼夜节律调控、基因表达、细胞分化、胚胎发育、应激反应及肿瘤发生中发挥作用。目前已有研究证实m6A甲基化通过调控ncRNAs在肿瘤生长、侵袭和转移中具有重要作用。本文将对m6A甲基化在肿瘤中修饰ncRNAs的最新研究进展进行综述。
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| 关 键 词： | m6A甲基化 非编码RNA 肿瘤 |
Advances in non-coding RNA modified by m6A in tumor |
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| YI Youcai,ZHANG Jing,CHEN Xiaoyu,ZHU Jinshui.Advances in non-coding RNA modified by m6A in tumor[J].Journal of Modern Oncology,2021,0(10):1825-1828. |
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| Authors: | YI Youcai ZHANG Jing CHEN Xiaoyu ZHU Jinshui |
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| Institution: | Department of Gastroenterology，Shanghai Jiao Tong University Affiliated Sixth People's Hospital，Shanghai 200233，China. |
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| Abstract: | Non-coding RNAs (ncRNAs) play an important role in cell differentiation，angiogenesis，immune response，inflammatory response and tumor development and metastasis.m6A (N6-methyladenosine) is one of the most common RNA modifications in eukaryotes,especially in messenger RNA(mRNA).m6A methylation modification is mainly carried out by three enzymes，including methyltransferase，demethylase and methylated recognition enzyme，and acts a role in circadian rhythm regulation，gene expression，cell differentiation，embryonic development，stress response and tumorigenesis.At present，it has been confirmed that m6A methylation acts in tumor growth，invasion and metastasis by regulating ncRNAs.In this paper，we will review the latest research progress about how m6A methylation modifies ncRNAs in cancer. |
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| Keywords: | m6A methylation non-coding RNA tumor |
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