| 高压氧对颅脑损伤大鼠认知功能的影响 |
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| 引用本文： | 尤春景,秦杰,黄杰,秦开容,陆敏. 高压氧对颅脑损伤大鼠认知功能的影响[J]. 中国康复, 2005, 20(6): 323-325 |
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| 作者姓名： | 尤春景 秦杰 黄杰 秦开容 陆敏 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院康复医学科,湖北,武汉,430030 |
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| 基金项目： | 湖北省卫生厅科研基金项目（JXIB044） |
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| 摘 要： | 目的：观察高压氧对颅脑损伤大鼠认知功能的影响。方法：30只SD大鼠采用Feeney自由落体撞击法造模，随机分为脑外伤组（A组）、脑外伤加高压氧治疗组（B组）和假手术对照组（C组）各10只，于造模24d后同时在水迷宫内进行定位航行和空间搜索实验。结果：在相同时间点寻找水下平台的潜伏期，B组大鼠均少于A组；在空间搜索实验中，跨越水下平台位置的次数B组明显高于A组（均P〈0．01）。结论：高压氧能够改善颅脑损伤大鼠学习记忆功能障碍，对神经功能具有保护作用。
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| 关 键 词： | 脑外伤 高压氧 认知 水迷宫 |
| 文章编号： | 1001-2001（2005）06-0323-03 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2005-06-13 |
Effects of Hyperbaric Oxygen in Rats with Cognitive Dysfunction after Traumatic Brain Injury |
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| YOU Chun-jing, QING Jie, HUANG Jie. Effects of Hyperbaric Oxygen in Rats with Cognitive Dysfunction after Traumatic Brain Injury[J]. Chinese Journal of Rehabilitation, 2005, 20(6): 323-325 |
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| Authors: | YOU Chun-jing QING Jie HUANG Jie |
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| Affiliation: | Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective: To observe the effect of hyperbaric oxygen(HBO) in rats with cognitive dysfunction after traumatic brain injury.Methods: The traumatic brain injury model was established by use of Feeney' method in rats.Thirty male rats were recruited in this study and randomly divided into 3 groups: traumatic brain injury group(group A),traumatic brain injury+HBO group(group B),and sham-operation group(group C).The learning and memory in groups A,B and C were tested by Morris water maze 24 days after development of the model.Results: Rats in group B used less time than rats in group A in the latency of escape at the same time.In the spatial probe test,the times across the original platform in the group B were more than those in the group A.Conclusion: HBO treatment can effectively improve the cognitive dysfunction after traumatic brain injury. |
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| Keywords: | traumatic brain injury hyperbaric oxygen cognitive function Morris water maze |
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