Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions |
| |
Authors: | Cheong Ying C Shelton Jenny B Laird Susan M Li Tin Chiu Ledger William L Cooke Ian D |
| |
Affiliation: | Department of Obstetrics and Gynaecology, St. Mary's Hospital, Milton Road, Portsmouth, Hampshire, United Kingdom. yingcheong@hotmail.com |
| |
Abstract: | OBJECTIVE: To establish whether the concentration of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) is influenced by the presence or absence of adhesions, and whether the concentration of these mediators vary throughout the menstrual cycle. DESIGN: Prospective case-control study. SETTING: Women undergoing laparoscopy in a university hospital in the United Kingdom. PATIENT(S): Women undergoing laparoscopy for benign gynecological conditions. INTERVENTION(S): Samples of peritoneal fluid were collected at diagnostic laparoscopy in one group, and at laparoscopy and serially during the first 48 hours after laparoscopic adhesiolysis in a second group. We correlated the concentrations of mediators in serially sampled peritoneal fluid during the 48 hours following laparoscopic adhesiolysis to the adhesion formation and reformation found during second-look laparoscopy. MAIN OUTCOME MEASURE(S): The concentrations of MMP-9, TIMP-1, and TGF-beta in peritoneal fluid. RESULT(S): MMP-9 concentration was lower in the follicular phase than the luteal phase of the menstrual cycle. MMP-9 concentration was significantly lower in women with pelvic adhesions than in women with a normal pelvis. The MMP-9/TIMP-1 ratio is significantly higher in women with significant adhesions at second-look laparoscopy compared to women with minimal or no adhesions. CONCLUSION(S): The components of extracellular matrix remodeling may play an important part in the adhesion formation/reformation process. |
| |
Keywords: | Adhesion MMP TIMP TGF peritoneal fluid second-look laparoscopy peritoneal drain |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|