The potential of viral metagenomics in blood transfusion safety |
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Authors: | V. Sauvage J. Gomez L. Boizeau S. Laperche |
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Affiliation: | Département d’études des agents transmissibles par le sang, Institut national de la transfusion sanguine (INTS), Centre national de référence risques infectieux transfusionnels, 75015 Paris, France |
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Abstract: | Thanks to the significant advent of high throughput sequencing in the last ten years, it is now possible via metagenomics to define the spectrum of the microbial sequences present in human blood samples. Therefore, metagenomics sequencing appears as a promising approach for the identification and global surveillance of new, emerging and/or unexpected viruses that could impair blood transfusion safety. However, despite considerable advantages compared to the traditional methods of pathogen identification, this non-targeted approach presents several drawbacks including a lack of sensitivity and sequence contaminant issues. With further improvements, especially to increase sensitivity, metagenomics sequencing should become in a near future an additional diagnostic tool in infectious disease field and especially in blood transfusion safety. |
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Keywords: | Viral metagenomics High throughput sequencing Viral discovery Blood-borne viruses Emerging viruses Blood safety Métagénomique Séquençage haut débit Découverte de virus Virus transmis par le sang Virus émergents Sécurité transfusionnelle |
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