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Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
Authors:Barbara Schormair  Chen Zhao  Steven Bell  Erik Tilch  Aaro V Salminen  Benno Pütz  Yves Dauvilliers  Ambra Stefani  Birgit Högl  Werner Poewe  David Kemlink  Karel Sonka  Cornelius G Bachmann  Walter Paulus  Claudia Trenkwalder  Wolfgang H Oertel  Magdolna Hornyak  Maris Teder-Laving  Catherine H Wilson
Affiliation:1. Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany;2. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany;3. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany;4. National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK;5. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK;6. Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK;7. NHS Blood and Transplant, Oxford, UK;8. NHS Blood and Transplant, Cambridge, UK;9. National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK;10. Max Planck Institute of Psychiatry, Munich, Germany;11. Sleep-Wake Disorders Centre, Department of Neurology, Hôpital Gui-de-Chauliac, INSERM U1061, CHU Montpellier, France;12. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria;13. Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic;14. Department of Neurology, Paracelsus Klinik, Osnabrueck, Germany;15. Department of Clinical Neurophysiology, University Medical Centre, Georg August University Göttingen, Göttingen, Germany;p. Clinic for Neurosurgery, University Medical Centre, Georg August University Göttingen, Göttingen, Germany;q. Paracelsus-Elena Hospital, Centre of Parkinsonism and Movement Disorders, Kassel, Germany;r. Department of Neurology, Philipps University Marburg, Marburg, Germany;s. Department of Neurology, University of Ulm, Ulm, Germany;t. Neuropsychiatry Centre Erding/München, Erding, Germany;u. Estonian Genome Centre, University of Tartu and Estonian Biocentre, Tartu, Estonia;v. Laboratory of Neurogenetics, Department of Neurology, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, Biopolis, Larissa, Greece;w. Unesta Research Centre, Tampere, Finland;x. Department of Pulmonary Diseases, Tampere University Hospital, Tampere, Finland;y. Department of Cardiology and Angiology, Centre of Sleep Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany;z. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA;11. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA;12. British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke''s Hospital, Cambridge, UK;13. Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK;14. Radcliffe Department of Medicine, BRC Haematology Theme and NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, UK;15. Department of Haematology and BRC Haematology Theme, Churchill Hospital, Oxford, UK;16. Center for Restless Legs Study, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA;17. Department of Neurology, Methodist Neurological Institute, Houston, TX, USA;18. Laboratoire de Neurogénétique, Centre de Recherche, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada;19. Département de Psychiatrie, Université de Montréal, Montréal, QC, Canada;110. Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada;111. Department of Human Genetics, McGill University, Montréal, QC, Canada;112. Hôpital du Sacré-Coeur de Montréal, 67120, Center for Advanced Research in Sleep Medicine, Montréal, QC, Canada;113. Montreal Neurological Institute, McGill University, Montréal, QC, Canada;114. Department of Health, National Institute for Health and Welfare, Helsinki, Finland;115. Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic;1p. Institute of Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland;1q. Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic;1r. Inserm UMR1087, CNRS UMR 6291, Institut du Thorax, Nantes, France;1s. Centre Hospitalier Universitaire (CHU) Nantes, Université de Nantes, France;1t. Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany;1u. PopGen Biobank and Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany;1v. John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada;1w. Department of Medicine, Duke University School of Medicine, Durham, NC, USA;1x. Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA;1y. German Centre for Diabetes Research (DZD), Neuherberg, Germany;1z. German Centre for Cardiovascular Disease Research (DZHK), Berlin, Germany;21. Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany;22. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;23. Institute of Translational Medicine, University of Liverpool, Liverpool, UK;24. Institute of Human Genetics, Technische Universität München, Munich, Germany;25. Neurologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany;26. 23andMe, Mountain View, CA, USA
Abstract:
Keywords:in collaboration with the
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