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Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
Authors:Giovanni B Frisoni  Marina Boccardi  Frederik Barkhof  Kaj Blennow  Stefano Cappa  Konstantinos Chiotis  Jean-Francois Démonet  Valentina Garibotto  Panteleimon Giannakopoulos  Anton Gietl  Oskar Hansson  Karl Herholz  Clifford R Jack  Flavio Nobili  Agneta Nordberg  Heather M Snyder  Mara Ten Kate  Andrea Varrone  Bengt Winblad
Affiliation:1. Department of Psychiatry, University Hospitals and University of Geneva, Geneva, Switzerland;2. Laboratory of Neuroimaging of Aging (LANVIE), University Hospitals and University of Geneva, Geneva, Switzerland;3. Department of Internal Medicine, University Hospitals and University of Geneva, Geneva, Switzerland;4. Nuclear Medicine and Molecular Imaging Division, University Hospitals and University of Geneva, Geneva, Switzerland;5. Department of Internal Medicine, University Hospitals and University of Geneva, Geneva, Switzerland;6. Service of Geriatrics, Department of Internal Medicine Rehabilitation and Geriatrics, University Hospitals and University of Geneva, Geneva, Switzerland;7. Institute for Ethics, History, and the Humanities, University Hospitals and University of Geneva, Geneva, Switzerland;8. Laboratory of Alzheimer Neuroimaging and Epidemiology (LANE), IRCCS S Giovanni di Dio–Fatebenefratelli, Brescia, Italy;9. Bioethics Unit, IRCCS S Giovanni di Dio–Fatebenefratelli, Brescia, Italy;10. Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, Netherlands;11. Department of Neurology, Alzheimer Centre, VU University Medical Centre, Amsterdam, Netherlands;12. Institute of Neurology, University College London, London, UK;13. Institute of Healthcare Engineering, University College London, London, UK;14. Alzheimer''s Switzerland, Yverdon-les-Bains, Switzerland;15. European Society of Neuroradiology, Zurich, Switzerland;p. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden;q. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;r. International Federation of Clinical Chemistry and Laboratory Medicine Working Group for CSF proteins (IFCC WG-CSF), Gothenburg, Sweden;s. Istituto Universitario di Studi Superiori di Pavia, Pavia, Italy, on behalf of Federation of European Neuropsychological Societies;t. Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden;u. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden;v. PET Centre, Department of Clinical Neurosciences, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden;w. Leenards Memory Centre, Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;x. Institute for Regenerative Medicine-IREM, University of Zurich Campus Schlieren, Zurich, Switzerland;y. Memory Clinic, Skåne University Hospital, Lund, Sweden;z. Department of Neurology, Skåne University Hospital, Lund, Sweden;11. Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden;12. Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK;13. Department of Radiology, Mayo Clinic, Rochester, MN, USA;14. Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy;15. IRCCS AOU San Martino-IST, Genoa, Italy, on behalf of the European Association of Nuclear Medicine;16. Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden;17. Department of Neurobiology, Care Siences and Society, Centre for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden;18. Alzheimer''s Association, Chicago, IL, USA;19. Clinical Epidemiology, University of Amsterdam, Amsterdam, Netherlands, on behalf of the European Federation of Laboratory Medicine;110. Clinical Neuroscience Department, Vita-Salute San Raffaele University, Milan, Italy;111. Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy;112. Institut de la Mémoire et de la Maladie d''Alzheimer, Hôpital Pitié Salpêtrière, UPMC University Paris 6, Paris, France;113. Centre for Primary Care and Public Health, Barts and The London School of Medicine, Blizard Institute, Queen Mary University of London, London, UK;114. Diagnostic and Interventional Neuroradiology, University Hospital of Geneva, Geneva, Switzerland;115. Department of Radiology, University Hospital of Geneva, Geneva, Switzerland;1p. Division of Nuclear Medicine, University Hospital of Geneva, Geneva, Switzerland;1q. Barcelona Beta Brain Research Centre, Pasqual Maragall Foundation, Barcelona, Spain;1r. Memory Clinic, University Centre for Medicine of Ageing, Felix Platter Hospital, Basel, Switzerland;1s. Department of Old Age Psychiatry, University of Bern, Bern, Switzerland;1t. Department of Clinical Neurosciences, Faculty of Medicine, University of Brescia, Brescia, Italy;1u. Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta;1v. Alzheimer Europe, Luxembourg, Luxembourg;1w. Division of Nuclear Medicine and Molecular Imaging, Stanford University, Standford, CA, USA;1x. German Center for Neurodegenerative Diseases (DZNE)—Rostock/Greifswald, Rostock, Germany;1y. Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany;1z. Faculty of Medicine, Imperial College London, London, UK;21. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands;22. St Jude Children''s Research Hospital, Memphis, TN, USA;23. European Alzheimer''s Disease Consortium
Abstract:
Keywords:Correspondence to: Prof Giovanni B Frisoni   LANVIE - Laboratory of Neuroimaging of Aging University of Geneva   and University Hospital   Chemin du Petit-Bel-Air   2   1225 Geneva   Switzerland
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