| 小柴胡汤对免疫抑制小鼠的免疫调节作用 |
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| 引用本文： | 唐小云,王志龙,李福娟. 小柴胡汤对免疫抑制小鼠的免疫调节作用[J]. 牡丹江医学院学报, 2008, 29(3): 4-6 |
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| 作者姓名： | 唐小云 王志龙 李福娟 |
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| 作者单位： | 牡丹江医学院病原生物学教研室,黑龙江,牡丹江,157011 |
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| 基金项目： | 牡丹江医学院一般科研项目 |
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| 摘 要： | 目的:探讨小柴胡汤对免疫抑制小鼠免疫功能的影响.方法:BALB/c小鼠肌肉注射环磷酰胺建立免疫抑制小鼠模型,同时给予小柴胡汤,连续7日,并设免疫抑制模型及正常对照组.检测各组脾脏T淋巴细胞增殖能力及Till型(IL-2、IFN-r)和TH2(IL-4、IL-10)型细胞因子产生水平.结果:与正常对照小鼠比较,免疫抑制小鼠T细胞增殖能力明显下降,T淋巴细胞增殖能力及TH1和TH2型细胞因子产生均明显降低(P<0.01).给予小柴胡汤的正常小鼠T淋巴细胞增殖能力提高,TH1和TH2型细胞因子产生也有所增加,但与正常组比较没有显著差异(P>0.05).与免疫抑制小鼠相比较,给予小柴胡汤的免疫抑制小鼠的T淋巴细胞增殖能力及TH1和TH2型细胞因子的产生均明显增加,(P<0.01).结论:小柴胡汤可以有效地增强免疫抑制小鼠免疫功能.
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| 关 键 词： | 小柴胡汤 免疫抑制 T淋巴细胞增殖反应 细胞因子 |
THE IMMUNOLOGICAL REGULATION OF BUPLEURI DECOCTION ON THE IMMUNOSUPPRESSED MICE |
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| Tang Xiaoyun et al. THE IMMUNOLOGICAL REGULATION OF BUPLEURI DECOCTION ON THE IMMUNOSUPPRESSED MICE[J]. Journal of Mudanjiang Medical College, 2008, 29(3): 4-6 |
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| Authors: | Tang Xiaoyun et al |
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| Affiliation: | Tang Xiaoyun et al (Mudanjiang Medical College,Mudanjiang Heilongjiang 157011) |
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| Abstract: | Objective:To explore the influence of Bupleuri Decoction on the immunological function of the immunosuppressed mice.Methods:BALB/c mice were induced immunosuppressed mice with cyclophosphamide i.m..And at the same time Bupleuri Decoction were administrated for 7 days and once every day.The immunosuppressed mice and normal mice were established.At the eighth day proliferating activity of T lymphocytes and the concentration of TH1 and TH2 cytokines were detected.Results:Compared with normal control,the T lymp... |
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| Keywords: | Bupleuri Decoction Immunosuppression T lymphocytes proliferating activity Cytokines |
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