| 重组人粒细胞集落刺激因子对局灶性脑缺血大鼠的抗凋亡作用 |
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| 引用本文： | 袁霞,张世明,董万利,方琪. 重组人粒细胞集落刺激因子对局灶性脑缺血大鼠的抗凋亡作用[J]. 中国神经再生研究, 2011, 6(11): 839-844 |
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| 作者姓名： | 袁霞 张世明 董万利 方琪 |
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| 作者单位： | 苏州大学附属第一医院神经内科,苏州大学附属第一医院神经内科,苏州大学附属第一医院神经内科,苏州大学附属第一医院神经内科 |
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| 摘 要： | The neuroprotective effects of granulocyte colony-stimulating factor in cerebral ischemia/reperfusion injury are currently contentious. The present study examined the effects of subcutaneous injection of recombinant human granulocyte colony-stimulating factor (50 μg/kg) over 5 days in a model of cerebral ischemia/reperfusion with intraluminal filament occlusion in rats. The results indicated that recombinant human granulocyte colony-stimulating factor reduced brain infarct volume following cerebral ischemia/reperfusion injury in rats, down-regulated the expression of caspase-3 mRNA (a key protease for apoptosis in the cerebral ischemia zone), lowered the rate of neuronal apoptosis in the cerebral ischemia zone, and notably ameliorated neurological function. These results indicate that recombinant human granulocyte colony-stimulating factor has anti-apoptotic effects on neurons following focal cerebral ischemia/reperfusion injury, and exerts neuroprotective effects.
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| 关 键 词： | recombinant human granulocyte colony-stimulating factor cerebral ischemia/ reperfusion injury anti-apoptosis neural regeneration |
Anti-apoptotic effects of recombinant human granulocyte colony-stimulating factor in focal cerebral ischemic rats |
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| yuanxi,zhangshiming,dongwanli and fangqi. Anti-apoptotic effects of recombinant human granulocyte colony-stimulating factor in focal cerebral ischemic rats[J]. Neural Regeneration Research, 2011, 6(11): 839-844 |
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| Authors: | yuanxi zhangshiming dongwanli fangqi |
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| Affiliation: | Department of Neurology and Department of Neurosurgery,Suzhou University Affiliated First Hospital,Department of Neurology and Department of Neurosurgery,Suzhou University Affiliated First Hospital,Department of Neurology and Department of Neurosurgery,Suzhou University Affiliated First Hospital,Department of Neurology and Department of Neurosurgery,Suzhou University Affiliated First Hospital |
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| Abstract: | |
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| Keywords: | recombinant human granulocyte colony-stimulating factor cerebral ischemia/ reperfusion injury anti-apoptosis neural regeneration |
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