Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired von Willebrand syndrome: response to septal myectomy |
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| Authors: | Blackshear Joseph L Schaff Hartzell V Ommen Steve R Chen Dong Nichols William L |
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| Affiliation: | From the Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL (J.L.B.); Division of Cardiovascular Surgery (H.V.S.), Division of Cardiovascular Diseases (S.R.O.), Division of Hematopathology (D.C., W.L.N.), and Division of Hematology (W.L.N.), Mayo Clinic, Rochester, MN |
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| Abstract: | Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome. |
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