Lymphomas and glioblastomas: differences in the apparent diffusion coefficient evaluated with high b-value diffusion-weighted magnetic resonance imaging at 3T

Background and purpose

As the usefulness of the apparent diffusion coefficient (ADC) obtained from diffusion-weighted images (DWI) for the differential diagnosis between glioblastoma and primary central nervous system lymphoma is controversial, we assessed whether high b-value DWI at b 4000 s/mm² could discriminate between glioblastoma and lymphoma. We also compared the power of high- and standard b-value (b-4000, b-1000) imaging on a 3-Tesla (3 T) magnetic resonance (MR) instrument.

Materials and methods

This study was approved by our Institutional Review Board. We acquired DWI at 3 T with b = 1000 and b = 4000 s/mm² in 10 patients with lymphoma and 14 patients with glioblastoma. The ADC was measured by placing multiple regions of interest (ROI) on ADC maps of the site of enhanced lesions on contrast-enhanced T1-weighted MR images. We avoided hemorrhagic and cystic lesions by using T1-, T2-, FLAIR-, and T2* MR images. The ADC values of each tumor were determined preoperatively from several ROI and expressed as the minimum-, mean-, and maximum ADC value (ADC_MIN, ADC_MEAN, ADC_MAX). We evaluated the relationship between ADCs and histological information including tumor cellularity.

Results

All ADC values were statistically associated with tumor cellularity. ADC_MIN at b-4000 was associated with tumor cellularity more significantly than ADC_MIN at b-1000. All ADC values were lower for lymphoma than glioblastoma and the statistical difference was larger at b = 4000- than b = 1000 s/mm². According to the results of discriminant analysis, the log likelihood was greatest for ADC_MIN at b = 4000. At a cut-off value of ADC_MIN = 0.500 × 10⁻³ mm²/s at b-4000 it was possible to differentiate between lymphoma and glioblastoma (sensitivity 90.9%, specificity 91.7%).

Conclusions

Calculating the ADC value is useful for distinguishing lymphoma from glioblastoma. The lowest degree of overlapping and a better inverse correspondence with tumor cellularity were obtained with ADC_MIN at b-4000 s/mm² at 3 T MRI.