绝经后妇女雌激素缺乏与胆固醇酯转运蛋白水平改变的关系

目的　探讨雌激素是否影响血清胆固醇酯转运蛋白 (CETP)水平的调节。方法　采用放射免疫分析法测定了 196例包括绝经前 (5 2例 ,年龄 18～ 40y)、绝经后妇女 (87例 ,年龄 61～ 81y)及围绝经期妇女 (5 7例 ,年龄 41～ 60 y)的血清雌二醇(E2 )、促卵泡生成激素 (FSH) ;自制CETP单抗建立的ELISA法测定CETP水平 ,同时测定血脂类指标。结果　绝经后妇女CETP水平明显低于绝经前和围绝经期妇女 (P <0 0 0 0 1) ,E2 水平较绝经前和围绝经期妇女显著下降 (P <0 0 0 0 1) ,而FSH水平显著升高 (P <0 0 0 0 1) ,各组血脂水平亦有显著性差异。CETP与E2 呈正相关 (r =0 .2 4,P <0 0 0 1) ,与FSH呈负相关(r =- 0 .2 7,P <0 0 0 1) ,与年龄呈负相关 (r=- 0 .3 1,P <0 0 0 0 1)。结论　雌激素水平的下降可影响绝经后妇女血清CETP水平

Relationship between endogenous estrogen concentrations and serum cholesterol ester transfer protein concentrations in Chinese women

Objective To investigate the effect of changes of hormone on serum cholesterol ester transfer protein (CETP) in women.Method Serum concentrations of estradiol(E2),follicle-stimulating hormone (FSH),CETP and serum lipids were determined in 196 women(52 premenopausal,57 perimenopausal,87 postmenopausal).Results Serum CETP concentration was lower in postmenpoausal women than that in perimenopausal and premenopausal women(P<0.0001).The mean level of E2 in postmenopausal women was significantly lower than that in premenopausal and perimenopausal women (P<0.0001),while the FSH level markedly increased(P<0.0001).Furthermore,the CETP concentrations positively correlated with serum concentration of E2,while negatively correlated with serum concentration of FSH and age.Conclusion Estrogen may affect the concentrations of CETP in serum.