| 巨噬细胞移动抑制因子蛋白在胰腺癌组织表达的临床意义 |
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| 引用本文： | 金志清,智发朝,陈学清,王亚东. 巨噬细胞移动抑制因子蛋白在胰腺癌组织表达的临床意义[J]. 南方医科大学学报, 2004, 24(11): 1301-1303 |
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| 作者姓名： | 金志清 智发朝 陈学清 王亚东 |
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| 作者单位： | 南方医科大学南方医院全军消化研究所,广东,广州,510515 |
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| 摘 要： | 目的观察巨噬细胞移动抑制因子(MIF)在胰腺癌组织中的表达及临床意义。方法应用免疫组织化学技术对36例胰腺癌组织中的MIF蛋白表达进行研究。结果胰腺癌组织中的MIF表达率为69.4%(25/36),高于正常胰腺组织表达率0(0/10)。统计学分析显示,MIF蛋白表达与胰腺癌病理分级呈显著相关(P<0.01),与胰腺癌临床分期及有无局部淋巴结转移间无显著相关(P>0.05)。结论MIF蛋白表达有可能与胰腺癌的发生有关。
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| 关 键 词： | 胰腺癌 巨噬细胞移动抑制因子 免疫组织化学 |
| 文章编号： | 1000-2588(2004)11-1301-03 |
| 修稿时间： | 2004-04-19 |
Expression of macrophage migration inhibition factor in pancreatic carcinoma tissue |
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| JIN Zhi-qing,ZHI Fa-chao,CHEN Xue-qing,WANG Ya-dongInstitute for Digestive Disease of PLA,Nanfang Hospital,Southern Medical University,Guangzhou ,China. Expression of macrophage migration inhibition factor in pancreatic carcinoma tissue[J]. Journal of Southern Medical University, 2004, 24(11): 1301-1303 |
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| Authors: | JIN Zhi-qing ZHI Fa-chao CHEN Xue-qing WANG Ya-dongInstitute for Digestive Disease of PLA Nanfang Hospital Southern Medical University Guangzhou China |
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| Affiliation: | JIN Zhi-qing,ZHI Fa-chao,CHEN Xue-qing,WANG Ya-dongInstitute for Digestive Disease of PLA,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To observe the expression of macrophage migration inhibitory factor (MIF) in pancreatic carcinoma tissue and analyze the relationship between MIF expression and clinical manifestations. Methods MIF expression in pancreatic carcinoma and normal pancreatic tissue were detected with immunohistochemical method. Result The positivity rates of MIF in pancreatic carcinoma and normal pancreatic tissue were 69.4%(25/36) and 0(0/10) respectively. MIF expression was found to relate to the degree of cell differentiation of pancreatic carcinoma, but not to the clinical stages or the status of lymph node metastasis. Conclusion MIF might be related to the pathogenesis of pancreatic carcinoma. |
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| Keywords: | pancreatic carcinoma macrophage migration inhibitory factor immunohistochemistry |
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