Association of Ghrelin Receptor Promoter Polymorphisms with Weight Loss Following Roux-en-Y Gastric Bypass Surgery期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Association of Ghrelin Receptor Promoter Polymorphisms with Weight Loss Following Roux-en-Y Gastric Bypass Surgery

Authors:	Michelle E. Matzko George Argyropoulos G. Craig Wood Xin Chu Roger J. M. McCarter Christopher D. Still Glenn S. Gerhard

Affiliation:	(1) Obesity Institute, Geisinger Clinic, 100 N. Academy Ave., Danville, PA 17822-2130, USA;(2) Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA;(3) Weis Center for Research, Geisinger Clinic, 100 N. Academy Ave., Danville, PA 17822-2130, USA;(4) Center for Health Research, Geisinger Clinic, Danville, PA, USA;

Abstract:	Background Ghrelin plays a role in appetite and has been hypothesized to play a role in the mechanism of Roux-en-Y gastric bypass (RYGB) surgery. Single nucleotide polymorphisms (SNPs) in the promoter region of its receptor gene (growth hormone secretagogue receptor type 1a—GHSR) have also been associated with weight loss outcomes following long-term dietary intervention in adults with impaired glucose tolerance. Our objectives were to evaluate changes in serum ghrelin levels and determine the effect of GHSR promoter polymorphisms on post-RYGB surgery weight loss.

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