| 孤独症患儿听觉P50变异及干预过程中的动态变化 |
| |
| 引用本文： | 吕梅,刘漪,杜亚松,陈兴时,楼翡璎,范娟,钱昀,赵志民,徐韬园.孤独症患儿听觉P50变异及干预过程中的动态变化[J].实用儿科临床杂志,2010(5). |
| |
| 作者姓名： | 吕梅 刘漪 杜亚松 陈兴时 楼翡璎 范娟 钱昀 赵志民 徐韬园 |
| |
| 作者单位： | 上海交通大学医学院附属精神卫生中心儿少精神科; |
| |
| 基金项目： | 上海市卫生局科研课题(2007020) |
| |
| 摘 要： | 目的探讨孤独症患儿听觉P50的特征及其临床意义,为孤独症的早期诊断找到脑电生理的依据。方法应用美国Nicolet Bravo刺激器,由信号发生器触发使其产生80 dB的成对短声S1(刺激1)和S2(刺激2),S1为条件刺激,S2为测试刺激。首先采用病例对照的方法,对入选的30例孤独症患儿及40名健康对照儿童进行听觉P50的检测,经过20周的系统干预治疗,采用自身对照的方法对30例孤独症患儿进行听觉P50的随访。采用SPSS11.0软件进行数据处理。结果1.孤独症患儿听觉P50抑制明显减弱;健康对照组S1-P50波幅为(5.9±3.6)μV,孤独症组为(3.1±2.4)μV(t=3.70,P<0.05);健康对照组S2-P50波幅为(2.6±2.0)μV,孤独症组为(5.0±3.1)μV(t=3.93,P<0.01);健康对照组波幅S1-S2的差值为(3.8±2.6)μV,孤独症组为(1.5±1.1)μV(t=4.54,P<0.01)。2.孤独症患儿组在干预20周后随访的P50主要指标(S1-P50、S2-P50波潜伏期及波幅,S2-P50波幅/S1-P50波幅的比值,波幅S1-S2的差值)与干预前比较差异均无...
|
| 关 键 词： | 孤独症 感觉门控 P50 属性标志 儿童 |
Auditory Evoked Potential P50 Mutations in Autistic Children and Dynamic Observation during the Intervention |
| |
| LV Mei,LIU Yi,DU Ya-song,CHEN Xing-shi,LOU Fei-ying,FAN Juan,QIAN Yun,ZHAO Zhi-min,XU Tao-yuan.Auditory Evoked Potential P50 Mutations in Autistic Children and Dynamic Observation during the Intervention[J].Journal of Applied Clinical Pediatrics,2010(5). |
| |
| Authors: | LV Mei LIU Yi DU Ya-song CHEN Xing-shi LOU Fei-ying FAN Juan QIAN Yun ZHAO Zhi-min XU Tao-yuan |
| |
| Institution: | LV Mei,LIU Yi,DU Ya-song,CHEN Xing-shi,LOU Fei-ying,FAN Juan,QIAN Yun,ZHAO Zhi-min,XU Tao-yuan(Department of Child , Adolescent Psychiatry,Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China) |
| |
| Abstract: | Objective To investigate the characteristics and clinical significance of auditory evoked potential P50 in autistic children,and to find out the relevant evidence of brain electrophysiology for early diagnosis on autism.Methods Auditory evoked potential P50 was recorded by the conditioning(S1)/testing(S2) paradigm presented with auditory double clicks stimuli,using American Nicolet Bravo instrument in 30 autistic children and 40 healthy children first.Follow-up of the auditory evoked potential P50 in autist... |
| |
| Keywords: | autism sensory gating P50 trait marker child |
| 本文献已被 CNKI 等数据库收录！ |
|
