| 血小板源生长因子受体抑制剂的研究近况 |
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| 引用本文： | 杜吕佩,夏霖.血小板源生长因子受体抑制剂的研究近况[J].药学进展,2003,27(1):9-15. |
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| 作者姓名： | 杜吕佩 夏霖 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
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| 摘 要： | 近年来的研究发现，酪氨酸蛋白激酶水平的升高已成为细胞增殖恶变的标志之一，其特异性的抑制剂对肿瘤有较高的预防及治疗价值。本文着重阐述了酪氨酸蛋白激酶受体中的血小板源生长因子受体抑剂的作用机制、分类、构效关系及上市药物等新进展。
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| 关 键 词： | 酪氨酸蛋白激酶 血小板源生长因子 血小板源生长因子受体制剂 |
| 文章编号： | 1001-5094(2003)01-0009-07 |
Recent Studies in Platelet-derived Growth Factor Receptor Inhibitors |
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| Abstract: | Recent studies showed that the increase of the protein tyrosine kinases level is one of the signals of the cellular proliferation and degeneration. The specific inhibition of growth related kinases,especially tyrosine kinases might provide new therapies for cancer.The present review summarizes and discusses the mechanism,classification and structure activity relationship(SAR) of one of the protein tyrosine kinases -- PDGFr inhibitors, and the related novel drugs. |
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| Keywords: | Protein tyrosine kinases Platelet derived growth factor Platelet derived growth factor receptor inhibitor |
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