| 香豆素磺酰脲类化合物的合成研究 |
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| 引用本文： | 韩莹,屠树滋. 香豆素磺酰脲类化合物的合成研究[J]. 中国药科大学学报, 2002, 33(5): 10-13 |
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| 作者姓名： | 韩莹 屠树滋 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
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| 摘 要： | 目的 合成新的香豆素磺酰脲类化合物供药理筛选。方法 通过改进的方法合成芳香异氰酸酯中间体，再与磺酰胺反应合成目标化合物。结果和结论 通过新的路线合成了18个香豆素磺酰脲类化合物（SU－22－39），所有目标化合物均未见文献报道，其结构经IR、^1HNMR和HRMS鉴定。进一步和降血糖活性研究正在进行。
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| 关 键 词： | 降血糖 香豆素磺酰脲 异氰酸酯 合成 |
| 文章编号： | 1000-5048(2002)05-0363-04 |
| 修稿时间： | 2002-01-18 |
Further Studies on the Preparation of Coumarin- 6- sulfonylureas |
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| HAN Ying,TU Shu-Zi. Further Studies on the Preparation of Coumarin- 6- sulfonylureas[J]. Journal of China Pharmaceutical University, 2002, 33(5): 10-13 |
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| Authors: | HAN Ying TU Shu-Zi |
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| Affiliation: | HAN Ying,TU Shu-ZiDepartment of Medicmai Chemistry,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | AIM To prepare a serious new coumarin-6-sulfonylureas. METHODS An improved process for the preparation of arylisocyanates was described. The title compounds were synthesized from coumarin- 6-sulfonamides by reaction with arylisocyanates. RESULTS and CONCLUSION A series of coumarin- 6-sulfonylureas(SU-22-39) were synthesized. Their structures are unreported and identified by IR, 1HNMR and HRMS spectra. The pharmacological study are carrying out. |
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| Keywords: | Hypoglycaema Coumarins-6-Sulfonylureas Isocyanates Synthesis |
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