HLA—DR基因多态性与广东汉族泛发型白癜风患者的相关性研究

目的研究广东籍汉族泛发型白癜风患者与HIA—DR的相关性。方法采用聚合酶链反应一序列特异性引物（PCR．SSP）技术，对30例广东籍汉族泛发型白癜风患者和30例健康对照者静脉血样本HLA-DR等位基因多态性进行研究。结果泛发型白癜风患者DRB1^＊0701等位基因频率显著升高（RR=5．216，PC〈0．05），DRw52（DRB3^＊0101／02DRB3^＊0201DRB3^＊0301）、DRw53（DRB4^＊0101／03／05）和DRw51（DRB5^＊0101／02DRB5^＊0202）基因频率明显低于正常组，以上三者两组间比较均有显著性差异（PC〈0．05）。结论HIJA—DRB1^＊0701等位基因可能与广东籍汉族泛发型白癜风的发病有关，而DRw52（DRB3^＊0101／02DRB3^＊0201DRB3^＊0301）、DRw53（DRB4^＊0101／03／05）和DRw51（DRB5^＊0101／02DRB5^＊0202）对泛发型白癜风发病可能有一定保护作用。

Polymorphism of HLA-DR in Generalized Vitiligo Patients of Han Nationality in Guangdong

Objective To study the HLA-DR genotypes in generalized vitiligo patients of Han Nationality in Guangdong. Methods Venous blood examples from 30 generalized vitiligo patients and 30 normal control subjects of Han Nationality were studied. HLA-DR gene polymorphism was analyzed by PCR-SSP method. Results The frequency of DRB1^＊0701 allele in generalized vitiligo patients was significantly higher than the control subjects （RR=5.216, Pc〈0.05）; while the frequency of DRw52 （DRB3^＊0101/02 DRB3^＊0201 DRB3^＊0301）, DRw53 （DRB4^＊0101/03/ 05）, DRw51 （DRB8^＊0101/02 DRB8^＊0202） was low （adjusted Pc〈0.05）. Conclusion DRB1 ~0701 allele is associated with the occurrence of generalized vitiligo. HLA-DRw52 （DRB3^＊0101/02, DRB3^＊0201, DRB3 ^＊030）, DRw53 （DRB4^＊0101/03/05） and DRw51 （DRB5^＊0101/02 DRBS＊0202） may play a protective role in reducing the incidence of generalized vitiligo.