| 不同pH值及氮酮对大黄酚透皮吸收影响 |
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| 引用本文： | 虞金宝,程怡,宋友昕. 不同pH值及氮酮对大黄酚透皮吸收影响[J]. 中草药, 1999, 30(5): 358-360 |
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| 作者姓名： | 虞金宝 程怡 宋友昕 |
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| 作者单位： | 江西省中医药研究所,南昌330077 |
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| 基金项目： | 国家自然科学基金!39360084，江西省自然科学基金 |
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| 摘 要： | 采用Ｖ－Ｃ扩散池及小鼠皮肤建立的透皮模型和紫外可见分光光度法，考察了不同ｐＨ值及其条件下氮酮对大黄提取物中大黄酚透皮吸收的影响。结果表明：大黄酚在酸性介质中的透皮效果最佳，且Ａｚｏｎｅ对其透皮吸收有显著增强作用。
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| 关 键 词： | 大黄酚 氮酮 pH值 透皮吸收 |
| 收稿时间： | 1998-08-24 |
Effects of pH and Azone on Transdermal Absorption of Chrysophanic Acid |
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| Yu Jinbao,Chengyi and Song Youxin. Effects of pH and Azone on Transdermal Absorption of Chrysophanic Acid[J]. Chinese Traditional and Herbal Drugs, 1999, 30(5): 358-360 |
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| Authors: | Yu Jinbao Chengyi Song Youxin |
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| Affiliation: | Institute of Traditional Chinese Medicine and Materia Medica of Jiangxi Province, Nanchang 330077;Institute of Traditional Chinese Medicine and Materia Medica of Jiangxi Province, Nanchang 330077;Institute of Traditional Chinese Medicine and Materia Medica of Jiangxi Province, Nanchang 330077 |
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| Abstract: | Effects of pH and azone on the transdermal absorption of chrysophanic acid by mouse skin were studied in vitro by Valian--Chien horizontal diffusion cell and UV spectrometry. Result of the study showed that maximum absorption was attained at pH4 and that azone is an excellent transdermal penetrant to enhance absorption. |
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| Keywords: | Azone transdermal absorption chrysophanic acid |
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