急性颅脑外伤患者血清NSE含量变化及临床意义

目的：探讨急性颅脑外伤患者血清神经元特异性烯醇化酶（Neuron-specificenolase,NSE）的含量及动态变化对颅脑损伤的诊断和评估伤情、观察疗效、预后判断的临床价值。方法：采用发光免疫分析,对60例急性颅脑外伤患者及62例正常人血清NSE含量进行同步检测。并于治疗前和治疗后3d、1周、2周、3周NSE的含量进行动态观察。对38例不同预后的急性颅脑外伤患者治疗前后的血清NSE浓度及GCS评分进行回顾分析。结果：急性颅脑外伤患者血清NSE含量显著增高,与正常对照组比较差异具有极显著意义（P〈0.001）,其NSE增高的程度,重型组〉中型组〉轻型组（P〈0.01）,与GCS评分密切负相关（r=-0.9140,P〈0.01）。动态观察显示56例不同程度的颅脑外伤患者治疗后血清NSE浓度随着治程的延续而逐渐下降,还发现急性颅脑外伤患者的血清NSE浓度如果高滴度持续增高,则预后不佳,反之则预后相对较好。而且NSE浓度下降越迅速,恢复正常的时间越早,其预后越佳。结论：血清NSE含量反映脑细胞损伤的程度,是一项灵敏的量化指标。进行NSE含量的检测不仅对脑损伤的诊断和评估伤情富有临床价值,而且对于疗效观察及预后的早期判断均有帮助。

Clinicla Significance of Measurement of Changes of Serum NSE Contents in Patients with Acute Cranio-Cerebral Injury

Objective To study the dynamic changes of serum neuro-specific enolace(NSE) contents in patients with acute cranio-cerebral injury and the relationship with Gascow score as well as clinical outcome.Methods Serum NSE contents were measured with CLIA in 60 patients with acute cerebral injury at admission and 3d,7d,14d,21d later as well as once in 62 controls.The Glascow score and clinical course of these patients were noted.Results The serum contents of NSE at admission were very significantly higher in the p...