Yuka, a New Platelet Antigen Involved in Two Cases of Neonatal Alloimmune Thrombocytopenia |
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| Authors: | Yoichi Shibata Isao Matsuda Toru Miyaji and Yoichi Ichikawa |
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| Affiliation: | Department of Immunohematology, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo;Department of Obstetrics and Gynecology, Morioka Red Cross Hospital, Iwate;Department of Pediatrics, Saitama Medical School, Saitama, Japan;Department of Bacteriology, Saitama Medical School, Saitama, Japan |
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| Abstract: | We report a new platelet antigen (Yuka) defined by the sera of 2 mothers whose babies developed alloimmune thrombocytopenia. These antiplatelet antibodies were IgG detected by Mixed Passive Hemagglutination (MPHA). In the study of two families, the Yuka antigen was found to be inherited as an autosomal dominant trait. The frequency of the Yuka phenotype in the Japanese population was estimated to be 1.7% (5/300). |
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