| 钛种植体表面原位包裹大鼠骨髓基质细胞的研究 |
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| 引用本文： | 吴明月,何家才,侯爱兵,陈莲子.钛种植体表面原位包裹大鼠骨髓基质细胞的研究[J].安徽医药,2010,14(10):1157-1159. |
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| 作者姓名： | 吴明月 何家才 侯爱兵 陈莲子 |
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| 作者单位： | 安徽医科大学口腔医学院,安徽,合肥,230032;安徽医科大学校医院,安徽,合肥,230032 |
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| 基金项目： | 安徽省高等学校省级自然科学研究项目 |
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| 摘 要： | 目的探讨钛种植体表面对大鼠骨髓基质细胞（bone marrow stromal cells,BMSCs）进行原位包裹的方法,为钛种植体表面组织工程支架构建提供实验基础。方法采用层层自组装技术在钛种植体表面构建以壳聚糖/海藻酸钠为组分的聚电解质多层膜结构,同时对BMSCs进行原位分层包裹,并通过扫描电镜及激光共聚焦显微镜观察包裹细胞的生长状态。结果扫描电镜及激光共聚焦显微镜观察证实BMSCs被成功包裹于钛种植体表面,并保持良好的生物学活性。结论钛种植体表面可以实现对BMSCs的原位分层包裹。
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| 关 键 词： | 钛 骨髓基质细胞 层层自组装 原位包裹 组织工程 |
Study of encapsulating bone marrow stromal cells in situ on titanium surface |
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| WU Ming-yue,HE Jia-cai,HOU Ai-bing,CHEN Lian-zi.Study of encapsulating bone marrow stromal cells in situ on titanium surface[J].Anhui Medical and Pharmaceutical Journal,2010,14(10):1157-1159. |
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| Authors: | WU Ming-yue HE Jia-cai HOU Ai-bing CHEN Lian-zi |
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| Institution: | WU Ming-yue1,HE Jia-cai1,HOU Ai-bing1,CHEN Lian-zi2(1.College of Stomatology,2.Hospital of University,Anhui Medical University,Hefei,Anhui 230032) |
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| Abstract: | Aim To explore the possibility of rat bone marrow stromal cells(BMSCs) encapsulated in situ on the titanium surfaces,and provide a basis for the preparation of tissue engineering scaffold on titanium surfaces.Methods A special biofilm-like scaffold with bone marrow stromal cells(BMSCs) encapsulated in situ was constructed on the titanium surface using a layer-by-layer(LBL) self-assembly technique.The cell-encapsulated scaffolds were evaluated by scanning electron microscopy(SEM) and confocal laser scanning ... |
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| Keywords: | titanium bone marrow stromal cells layer-by-layer self-assembly encapsulated in situ tissue engineering |
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