雌激素替代辅助治疗老年绝经女性再发性下尿路感染

目的研究雌激素替代辅助治疗老年女性再发性下尿路感染的疗效。方法绝经期后再发性下尿路感染患者146例,随机分为2组,治疗组采用7-甲异炔诺酮(livial,利维爱)或雌三醇(ovestin,欧维婷)联合抗生素,对照组则只采用抗生素治疗。随访观察治疗后6月内的情况。结果随着时间的推移,雌激素辅助治疗组下尿路感染的再发生率逐渐降低,3月时差异最显著;但雌激素停用3月后2组的再发感染率又归于相近。结论对于在治疗老年女性再发性下尿路感染时长期使用雌激素辅助疗法的利弊,临床上尚需要进一步研究。

Estrogen replacement therapy for recurred urinary tract infections in postmenopausal women

Objective To investigate the curative effect of estrogen replacement therapy on recurred urinary tract infections in postmenopausal women. Methods 146 postmenopausal women who had recurred urinary tract infections were enrolled and were divided into treatment group and control group. The treatment group adopted antibiotic and tibolone tablets or estriol cream, while the control group used antibiotic alone. Effect was evaluated after 6 months' treatment. Results Infections recurrence rate reduced in treatment group as estrogen was used. There was significant difference in infection recurrence rates between the two groups 3 months later.But infection recurrence rates were similar in 3 months while estrogen was withdrawn. Conclusions The urinary tract infections in postmenopausal women decresed while estrogen used but reincreased as the estrogen was withdrawn. The value of long-term estrogen replacement treatment on postmenopausal women who have recurred urinary tract infections need more investigation.