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p16蛋白在子宫内膜癌中的表达及其临床意义
引用本文:李建生 李娜. p16蛋白在子宫内膜癌中的表达及其临床意义[J]. 肿瘤研究与临床, 1999, 11(3): 171-172
作者姓名:李建生 李娜
作者单位:河南省开封市妇产医院
摘    要:目的研究p16抑癌基因蛋白与子宫内膜癌的关系。方法应用免疫组化SP法对64例子宫内膜癌、22例非典型增生内膜和30例正常内膜组织做p16蛋白检测。结果p16在内膜癌中阳性率为46.87%,明显低于正常内膜100%和非典型增生72.73%(P<0.01,P<0.05)。结论p16蛋白的缺失与突变可能与内膜癌的发生、发展密切相关,是检测内膜癌的重要标志。

关 键 词:子宫内膜癌  p16蛋白  免疫组化

EXPRESSION OF p16 PROTEIN IN ENDOMETRIAL CARCINOMAS AND ITS CLINICAL SIGNIFICANCE
Li Jiansheng,Li Na,Zhang Donghong Obstetric and Gynecologic Hospital of Kaifeng City. EXPRESSION OF p16 PROTEIN IN ENDOMETRIAL CARCINOMAS AND ITS CLINICAL SIGNIFICANCE[J]. Cancer Research and Clinic, 1999, 11(3): 171-172
Authors:Li Jiansheng  Li Na  Zhang Donghong Obstetric  Gynecologic Hospital of Kaifeng City
Abstract:Objective To study the clinical significance of p16 expression in endometrial carcinoma. Methods SP immunohistochemistry was employed to detect the expression of p16 protein in tissues of 64 cases of endometrial carcinoma,30 cases of normal endometrium and 22 cases of atypical hyperpiasia of endometrium. Results The positive rate of p16 was significantly lower in endometrial carcinoma(46.87%) than that in normal endometrium(100%),and atypical hyperplasia endometrium(72.73%) (P<0.01) . Conclusion The mutation and deletion of p16 protein may be related to the genesis and development of endometrial carcinoma. The p16 gene may play an important role in molecular bioscience of the endometrial carcinoma.
Keywords:Endometrial carcinomap16 protein Immunohistochemistry  
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